1Department of Geriatrics,Zhongshan Hospital,Fudan University,Shanghai 200032,People's Republic of China.
2Department of Endocrinology and Metabolism,Zhongshan Hospital,Fudan University,Shanghai 200032,People's Republic of China.
Br J Nutr. 2018 Oct;120(8):863-871. doi: 10.1017/S0007114518002167. Epub 2018 Sep 7.
Associations between ferritin and insulin sensitivity have been described in recent studies. The possible association showed conflicting results by sex and menopausal status. We aimed to investigate the cross-sectional association of ferritin levels with insulin resistance and β-cell function. A total of 2518 participants (1033 men, 235 pre-menopausal women and 1250 post-menopausal women) were enrolled from the Changfeng Study. A standard interview was conducted, as well as anthropometric measurements and laboratory analyses, for each participant. The serum ferritin level was measured using electrochemiluminescence immunoassay. Insulin resistance and β-cell function indices were derived from a homeostasis model assessment. The results showed that the serum ferritin levels were 250·4 (sd 165·2), 94·6 (sd 82·0) and 179·8 (sd 126·6) ng/ml in the men, pre-menopausal and post-menopausal women, respectively. In fully adjusted models (adjusting for age, current smoking, BMI, waist:hip ratio, systolic blood pressure, diastolic blood pressure, TAG, HDL-cholesterol, LDL-cholesterol, log urine albumin:creatinine ratio, leucocytes, alanine aminotransferase, aspartate aminotransferase and γ-glutamyl transpeptidase), serum ferritin concentrations are significantly associated with insulin resistance in men and post-menopausal females, and the null association was observed in pre-menopausal females. Interestingly, an increased β-cell function associated with higher ferritin was observed in post-menopausal participants, but not in male participants. In conclusion, these results suggested that elevated serum ferritin levels were associated with surrogate measures of insulin resistance among the middle-aged and elderly male and post-menopausal women, but not in pre-menopausal women.
最近的研究表明，铁蛋白与胰岛素敏感性之间存在关联。这种关联在性别和绝经状态上的表现结果存在冲突。我们旨在研究铁蛋白水平与胰岛素抵抗和β细胞功能的横断面关联。这项研究共纳入了 2518 名参与者（男性 1033 人，绝经前女性 235 人，绝经后女性 1250 人），这些参与者均来自长风研究。对每位参与者进行了标准访谈、人体测量和实验室分析。使用电化学发光免疫分析法测量血清铁蛋白水平。胰岛素抵抗和β细胞功能指数来自稳态模型评估。结果显示，男性、绝经前和绝经后女性的血清铁蛋白水平分别为 250.4（标准差 165.2）、94.6（标准差 82.0）和 179.8（标准差 126.6）ng/ml。在完全调整的模型（调整年龄、当前吸烟、BMI、腰围：臀围比、收缩压、舒张压、TAG、HDL-胆固醇、LDL-胆固醇、尿白蛋白：肌酐比值的对数、白细胞、丙氨酸氨基转移酶、天冬氨酸氨基转移酶和γ-谷氨酰转肽酶）中，血清铁蛋白浓度与男性和绝经后女性的胰岛素抵抗显著相关，而在绝经前女性中则未观察到这种关联。有趣的是，在绝经后参与者中，随着铁蛋白的升高，β细胞功能也有所增加，但在男性参与者中则没有。总之，这些结果表明，在中年和老年男性以及绝经后女性中，较高的血清铁蛋白水平与胰岛素抵抗的替代指标相关，但在绝经前女性中则没有。
