Agoons Dayawa D, Agoons Batakeh B, Kaze Arnaud D, Komanduri Saketram
Internal Medicine, University of Pittsburgh Medical Center Pinnacle Hospital, Harrisburg, USA.
Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaounde, Yaoundé, CMR.
Cureus. 2021 Mar 12;13(3):e13855. doi: 10.7759/cureus.13855.
Background Accruing evidence suggests an inverse relationship between coffee intake and serum uric acid. The mechanism(s) explaining this inverse relationship remains elusive. The aim of this study was to assess if the association between coffee intake and hyperuricemia is mediated via serum ferritin in women. Methods We pooled data from the 2003 to 2006 National Health and Nutrition Examination Survey (NHANES). We included women with complete information on all key variables. Coffee intake was classified as none, <1 cup/day, 1-3 cups/day, and ≥4 cups/day. Hyperuricemia was defined as serum uric acid >5.7 mg/dL. We assessed the association between coffee intake and hyperuricemia using logistic regression. Path analysis was used to examine whether serum ferritin mediated the effect of coffee on hyperuricemia. Results Among 2,139 women (mean age: 31.2 years [SD: 9.2]), mean serum uric acid was 4.4 mg/dL (SD: 1.0), and 227 (10.6%) had hyperuricemia. In multivariate logistic regression models, intake of ≥4 cups/day of coffee was associated with lower odds of hyperuricemia (OR 0.28 [95% CI: 0.09, 091], P=0.035). The total direct and indirect effect of coffee on hyperuricemia via serum ferritin was -0.16, P=0.009 and -8.1 × 10 , P=0.204, respectively. Conclusion Among women, moderate coffee consumption was inversely related to hyperuricemia by direct effect, rather than indirectly through the effects of serum ferritin. These findings suggest that serum ferritin does not mediate the inverse association between coffee and hyperuricemia in women.
背景 越来越多的证据表明咖啡摄入量与血清尿酸之间存在负相关关系。解释这种负相关关系的机制仍不清楚。本研究的目的是评估女性中咖啡摄入量与高尿酸血症之间的关联是否通过血清铁蛋白介导。方法 我们汇总了2003年至2006年美国国家健康和营养检查调查（NHANES）的数据。我们纳入了所有关键变量信息完整的女性。咖啡摄入量分为无、<1杯/天、1 - 3杯/天和≥4杯/天。高尿酸血症定义为血清尿酸>5.7mg/dL。我们使用逻辑回归评估咖啡摄入量与高尿酸血症之间的关联。路径分析用于检验血清铁蛋白是否介导咖啡对高尿酸血症的影响。结果 在2139名女性（平均年龄：31.2岁[标准差：9.2]）中，平均血清尿酸为4.4mg/dL（标准差：1.0），227名（10.6%）患有高尿酸血症。在多变量逻辑回归模型中，每天饮用≥4杯咖啡与高尿酸血症的较低几率相关（比值比0.28[95%置信区间：0.09，0.91]，P = 0.035）。咖啡通过血清铁蛋白对高尿酸血症的总直接和间接效应分别为 - 0.16，P = 0.009和 - 8.1×10，P = 0.204。结论 在女性中，适量饮用咖啡与高尿酸血症呈负相关是通过直接效应，而非通过血清铁蛋白的间接效应。这些发现表明血清铁蛋白不介导女性中咖啡与高尿酸血症之间的负相关关系。
