醋酸亮丙瑞林（黄体生成素释放激素）治疗性偏好障碍性犯罪者的疗效。
Therapeutic Effects of Leuprorelin (Leuprolide Acetate) in Sexual Offenders with Paraphilia.
机构信息
Department of Psychiatry, National Forensic Hospital, Gongju, Korea.
Department of Psychiatry, National Forensic Hospital, Bugok, Korea.
出版信息
J Korean Med Sci. 2018 Jul 23;33(37):e231. doi: 10.3346/jkms.2018.33.e231. eCollection 2018 Sep 10.
BACKGROUND
This study examined the clinical effects of leuprolide acetate in sexual offenders with paraphilic disorders evaluated by means of objective psychiatric assessment.
METHODS
The subjects of this study were seven sexual offenders who were being treated by means of an injection for sexual impulse control by a court order. They had been diagnosed with paraphilia by a psychiatrist based on the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and had been put on probation by the Ministry of Justice between January 2016 and December 2016.
RESULTS
After twelve months, we observed significant improvement in symptoms, as decrease of abnormal sexual interest and activity, sexual fantasy, Clinical Global Impression-Severity (CGI-S), and Clinical Global Impression-Impulsivity (GCI-I). There were a mild feminization of the body shape, feelings of fatigue, and mild hot flushes. No other adverse effect was reported.
CONCLUSION
These results suggested that the clinical effects of leuprolide acetate in sexual offenders might be an effective treatment and safety strategy.
背景
本研究通过客观的精神评估，考察了醋酸亮丙瑞林在性犯罪者恋物癖障碍中的临床效果。
方法
本研究的对象是 7 名性犯罪者，他们因性冲动控制问题而根据《精神障碍诊断与统计手册》第 5 版（DSM-5）被精神病医生诊断患有恋物癖，并于 2016 年 1 月至 2016 年 12 月期间被司法部缓刑。
结果
12 个月后，我们观察到症状显著改善，异常性兴趣和活动、性幻想、临床总体印象严重程度（CGI-S）和临床总体印象冲动性（CGI-I）均有所下降。出现了轻微的身体女性化、疲劳感和轻微的潮热。没有报告其他不良反应。
结论
这些结果表明，醋酸亮丙瑞林在性犯罪者中的临床效果可能是一种有效的治疗和安全策略。
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