评估血清生物标志物用于检测孕妇先兆子痫严重程度的研究。
Evaluation of serum biomarkers for detection of preeclampsia severity in pregnant women.
作者信息
Kasraeian Maryam, Asadi Nasrin, Vafaei Homeira, Zamanpour Tarlan, Shahraki Hadi Raeisi, Bazrafshan Khadije
机构信息
Maryam Kasraeian, M.D. Associate Professor of Prenatalogy. Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Nasrin Asadi, M.D. Associate Professor of Prenatalogy. Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Pak J Med Sci. 2018 Jul-Aug;34(4):869-873. doi: 10.12669/pjms.344.14393.
OBJECTIVES
To determine serum biomarkers in detection of preeclampsia severity among pregnant women.
METHODS
Among 450 pregnant women with various severity of preeclampsia, serum biomarkers ofaspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), hemoglobin (Hb), platelet count (PLT), uric acid, direct bilirubin, total bilirubin, creatinine, and alkaline phosphatase were compared using area under the Receiver operating characteristic (ROC) curve and Area Under the Curve (AUC).
RESULTS
The mean age of women was 30.63±6.43 years and with mean gestational age of 34.69±3.97 weeks. The mean level of LDH, ALT, uric acid, and creatinine were significantly higher in the women with severe type of preeclampsia compared to those with mild type. LDH level had ROC and AUC of more than 0.80, with highest sensitivity, and moderatespecificityin comparison to other markers.
CONCLUSION
Biomarkers such as ALT, uric acid, and LDH were shown to be prognostic in detection of theseverity of preeclampsia. LDH was demonstrated to significantly be a better prognostic test in detection of preeclampsia severity.
目的
确定血清生物标志物在检测孕妇子痫前期严重程度中的作用。
方法
在450例患有不同严重程度子痫前期的孕妇中，使用受试者操作特征曲线下面积（ROC）和曲线下面积（AUC）比较天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、乳酸脱氢酶（LDH）、血红蛋白（Hb）、血小板计数（PLT）、尿酸、直接胆红素、总胆红素、肌酐和碱性磷酸酶的血清生物标志物。
结果
女性的平均年龄为30.63±6.43岁，平均孕周为34.69±3.97周。与轻度子痫前期女性相比，重度子痫前期女性的LDH、ALT、尿酸和肌酐平均水平显著更高。与其他标志物相比，LDH水平的ROC和AUC超过0.80，具有最高的敏感性和中等特异性。
结论
ALT、尿酸和LDH等生物标志物在子痫前期严重程度检测中具有预后价值。LDH被证明在子痫前期严重程度检测中是一种更好的预后检测指标。
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