乳酸脱氢酶：子痫前期-子痫的一种生化标志物。
Lactic dehydrogenase: a biochemical marker for preeclampsia-eclampsia.
作者信息
Jaiswar S P, Gupta Amrit, Sachan Rekha, Natu S N, Shaili Mohan
机构信息
Department of Obstetrics and Gynecology, Queen Mary Hospital, CSMMU, Lucknow, UP India.
出版信息
J Obstet Gynaecol India. 2011 Dec;61(6):645-8. doi: 10.1007/s13224-011-0093-9. Epub 2012 Jan 4.
OBJECTIVES
To correlate the severity of the disease, maternal and perinatal outcome with Lactic Dehydrogenase (LDH) levels in serum in patients of preeclampsia and eclampsia.
METHODS
A prospective comparative study was conducted in the department of Obstetrics and Gynecology in the collaboration with department of Pathology, CSM Medical University, Lucknow. Out of 146 women studied, 39 were normal pregnant women, 35 were of mild preeclampsia, 36 of severe preeclampsia and 36 of eclampsia. The statistical analysis was done by Chi-square test (for proportional data) analysis of variance and sample "t" test (for parametric data).
RESULTS
LDH levels were significantly elevated in women with preeclampsia and eclampsia (<0.001). Higher LDH levels had significant correlation with high blood pressure (P < 0.10) as well as poor maternal and perinatal outcome.
CONCLUSION
High serum LDH levels correlate well with the severity of the disease and poor outcomes in patients of preeclampsia and eclampsia.
目的
探讨子痫前期和子痫患者血清乳酸脱氢酶（LDH）水平与疾病严重程度、孕产妇及围产儿结局之间的相关性。
方法
在勒克瑙CSM医学院妇产科与病理科合作开展了一项前瞻性对照研究。在146名研究对象中，39名是正常孕妇，35名是轻度子痫前期患者，36名是重度子痫前期患者，36名是子痫患者。采用卡方检验（用于比例数据）、方差分析和样本t检验（用于参数数据）进行统计学分析。
结果
子痫前期和子痫患者的LDH水平显著升高（<0.001）。较高的LDH水平与高血压（P < 0.10）以及不良的孕产妇和围产儿结局显著相关。
结论
血清LDH水平升高与子痫前期和子痫患者的疾病严重程度及不良结局密切相关。
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