• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

肝干细胞与癌症:病理学家的观点。

Hepatic stem cells and cancers: a pathologist's view.

作者信息

Theise Neil D

机构信息

Departments of Pathology & Medicine (Division of Digestive Diseases), Mount Sinai Beth Israel Medical Center, First Avenue at 16th Street, New York, NY 10003, USA.

出版信息

Hepat Oncol. 2015 Oct;2(4):329-334. doi: 10.2217/hep.15.25.

DOI:10.2217/hep.15.25
PMID:30191013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6095186/
Abstract

Neil Theise is a diagnostic liver pathologist, adult stem cell researcher and complexity theorist in New York City, where he is a Professor of Pathology at the Mount Sinai Beth Israel Medical Center of Icahn School of Medicine at Mount Sinai. He received his medical degree from Columbia University College of Physicians and Surgeons, where he also received his training in Anatomic Pathology. Subspecialty training was pursued in gastrointestinal (NYU), liver (Royal Free Hospital) and liver transplant (Mount Sinai, NYC) pathology. His earliest research focus was on defining the premalignant dysplastic nodules in human chronic liver disease. He revised understandings of human liver microanatomy, which in turn, led directly to identification of possible liver stem cell niches and the marrow-to-liver regeneration pathway. He is considered a pioneer of multiorgan adult stem cell plasticity. His publications on these topics in model systems and human liver stem cells have been highlighted on a record five covers of .

摘要

尼尔·泰斯是纽约市的一名诊断肝脏病理学家、成体干细胞研究员和复杂性理论家,他是西奈山伊坎医学院西奈山贝斯以色列医疗中心的病理学教授。他在哥伦比亚大学医师和外科医生学院获得医学学位,并在那里接受了解剖病理学培训。他还在胃肠病学(纽约大学)、肝脏(皇家自由医院)和肝脏移植(纽约市西奈山)病理学领域接受了专科培训。他最早的研究重点是确定人类慢性肝病中的癌前发育异常结节。他修正了对人类肝脏微观解剖结构的认识,这反过来又直接导致了可能的肝脏干细胞龛位和骨髓到肝脏再生途径的发现。他被认为是多器官成体干细胞可塑性的先驱。他在模型系统和人类肝脏干细胞方面关于这些主题的出版物曾五次登上《》杂志的封面。

相似文献

1
Hepatic stem cells and cancers: a pathologist's view.肝干细胞与癌症:病理学家的观点。
Hepat Oncol. 2015 Oct;2(4):329-334. doi: 10.2217/hep.15.25.
2
Abass Alavi: A giant in Nuclear Medicine turns 80 and is still going strong!阿巴斯·阿拉维:核医学领域的一位巨擘迎来80岁生日,依然精力充沛!
Hell J Nucl Med. 2018 Jan-Apr;21(1):85-87. doi: 10.1967/s002449910713. Epub 2018 Mar 20.
3
Failure of the merger of the Mount Sinai and New York University hospitals and medical schools: part 2.西奈山医院和纽约大学医院及医学院合并失败:第 2 部分。
Acad Med. 2010 Dec;85(12):1828-32. doi: 10.1097/ACM.0b013e3181f65019.
4
Surgical pathology in the 20th century at the Mount Sinai Hospital, New York.20世纪纽约西奈山医院的外科病理学
Semin Diagn Pathol. 2008 Aug;25(3):178-89. doi: 10.1053/j.semdp.2008.06.003.
5
ATLANTIC and beyond: an interview with Professor Azfar Zaman.《大西洋及其他地区:对阿兹法尔·扎曼教授的采访》
Future Cardiol. 2015;11(1):13-5. doi: 10.2217/fca.14.75.
6
Dr. Andrew Huvos (1934-2006) retrospective: a tribute to the pathologist and the man.安德鲁·胡沃斯医生(1934 - 2006)回顾:向这位病理学家及他本人致敬。
Head Neck Pathol. 2013 Mar;7(1):1-4. doi: 10.1007/s12105-013-0425-4. Epub 2013 Mar 5.
7
Molecular cell biology and advanced microscopy: an interview with Joshua Z. Rappoport.分子细胞生物学与先进显微镜技术:对约书亚·Z·拉波波特的访谈
Biotechniques. 2018 May;64(5):194-196. doi: 10.2144/btn-2018-0054.
8
Leading the way in biomedical engineering: an interview with Robert Langer. Interview by Hannah Stanwix, Commissioning Editor.引领生物医学工程领域:罗伯特·兰格访谈。访谈者:汉娜·斯坦威克斯,委托编辑。
Nanomedicine (Lond). 2012 Oct;7(10):1483-4. doi: 10.2217/nnm.12.132.
9
[Life achievements of Dr. Dusan Kentera (1925-1999). Aspects of pulmonary circulation].[杜尚·肯特拉博士(1925 - 1999年)的生平成就。肺循环的各个方面]
Srp Arh Celok Lek. 2003 Mar-Apr;131(3-4):189-98.
10
Women's health research in the last four decades. Interview by Natasha Leeson.过去四十年的女性健康研究。娜塔莎·利森访谈。
Womens Health (Lond). 2014 Jan;10(1):13-6. doi: 10.2217/whe.13.66.

引用本文的文献

1
AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis.AK2 是肿瘤发生中 BRAF 的 AMP 感应负调节剂。
Cell Death Dis. 2022 May 18;13(5):469. doi: 10.1038/s41419-022-04921-7.
2
The cellular origins of cancer with particular reference to the gastrointestinal tract.癌症的细胞起源,特别是胃肠道。
Int J Exp Pathol. 2020 Oct;101(5):132-151. doi: 10.1111/iep.12364. Epub 2020 Aug 14.

本文引用的文献

1
Biphenotypic (hepatobiliary) primary liver carcinomas: the work in progress.双表型(肝胆型)原发性肝癌:进展中的工作。
Hepat Oncol. 2015 Jul;2(3):255-273. doi: 10.2217/hep.15.8. Epub 2015 Jul 28.
2
Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cells.纤维板层型肝细胞癌模型显示癌症干细胞显著富集。
Nat Commun. 2015 Oct 6;6:8070. doi: 10.1038/ncomms9070.
3
Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver.自我更新的二倍体Axin2(+)细胞为肝脏的稳态更新提供动力。
Nature. 2015 Aug 13;524(7564):180-5. doi: 10.1038/nature14863. Epub 2015 Aug 5.
4
Epigenetic reprogramming modulates malignant properties of human liver cancer.表观遗传重编程调节人类肝癌的恶性特性。
Hepatology. 2014 Jun;59(6):2251-62. doi: 10.1002/hep.27026. Epub 2014 May 1.
5
Assessing the potential of induced liver regeneration.评估诱导性肝再生的潜力。
Nat Med. 2013 Sep;19(9):1096-7. doi: 10.1038/nm.3325.
6
Low hepatocyte repopulation from stem cells: a matter of hepatobiliary linkage not massive production.干细胞来源的肝细胞再填充率低:这是肝胆联系的问题,而非大量生成的问题。
Gastroenterology. 2013 Jul;145(1):253-254. doi: 10.1053/j.gastro.2013.02.052. Epub 2013 May 31.
7
Primary liver carcinomas can originate from different cell types: a new level of complexity in hepatocarcinogenesis.原发性肝癌可起源于不同细胞类型:肝癌发生过程中的一个新的复杂层面。
Gastroenterology. 2013 Jul;145(1):53-55. doi: 10.1053/j.gastro.2013.05.024. Epub 2013 May 29.
8
Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types.在特定于谱系的小鼠细胞类型中模拟原发性肝癌的发病机制。
Gastroenterology. 2013 Jul;145(1):221-231. doi: 10.1053/j.gastro.2013.03.013. Epub 2013 Mar 19.
9
Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem/progenitor cells in humans.上皮细胞黏附分子 (EpCAM) 标记人类来源于干细胞/祖细胞的新生肝细胞。
Hepatology. 2011 Mar;53(3):964-73. doi: 10.1002/hep.24122. Epub 2011 Feb 11.
10
The histogenesis of regenerative nodules in human liver cirrhosis.肝硬化患者肝脏再生结节的组织发生。
Hepatology. 2010 Mar;51(3):1017-26. doi: 10.1002/hep.23483.