Janosik Tomasz, Rannug Agneta, Rannug Ulf, Wahlström Niklas, Slätt Johnny, Bergman Jan
Research Institutes of Sweden , Bioscience and Materials, RISE Surface, Process and Formulation , SE-151 36 Södertälje , Sweden.
Institute of Environmental Medicine , Karolinska Institutet , SE-171 77 Stockholm , Sweden.
Chem Rev. 2018 Sep 26;118(18):9058-9128. doi: 10.1021/acs.chemrev.8b00186. Epub 2018 Sep 7.
The indolocarbazoles are an important class of nitrogen heterocycles which has evolved significantly in recent years, with numerous studies focusing on their diverse biological effects, or targeting new materials with potential applications in organic electronics. This review aims at providing a broad survey of the chemistry and properties of indolocarbazoles from an interdisciplinary point of view, with particular emphasis on practical synthetic aspects, as well as certain topics which have not been previously accounted for in detail, such as the occurrence, formation, biological activities, and metabolism of indolo[3,2- b]carbazoles. The literature of the past decade forms the basis of the text, which is further supplemented with older key references.
吲哚咔唑是一类重要的氮杂环化合物,近年来其研究有了显著进展,众多研究聚焦于它们多样的生物效应,或致力于开发在有机电子学中有潜在应用的新材料。本综述旨在从跨学科角度对吲哚咔唑的化学性质进行全面概述,特别强调实际合成方面,以及一些此前未详细阐述的特定主题,如吲哚[3,2 - b]咔唑的存在、形成、生物活性和代谢。过去十年的文献构成了本文的基础,并进一步补充了一些较早的关键参考文献。