Sánchez César, Méndez Carmen, Salas José A
Departamento de Biología Funcional & Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A.), Universidad de Oviedo, 33006, Oviedo, Spain.
Nat Prod Rep. 2006 Dec;23(6):1007-45. doi: 10.1039/b601930g. Epub 2006 Oct 19.
The indolocarbazole family of natural products, including the biosynthetically related bisindolylmaleimides, is reviewed (with 316 references cited). The isolation of indolocarbazoles from natural sources and the biosynthesis of this class of compounds are thoroughly reviewed, including recent developments in molecular genetics, enzymology and metabolic engineering. The biological activities and underlying modes of action displayed by natural and synthetic indolocarbazoles is also presented, with an emphasis on the development of analogs that have entered clinical trials for its future use against cancer or other diseases.
对包括生物合成相关的双吲哚马来酰胺在内的吲哚咔唑类天然产物进行了综述（引用参考文献316篇）。全面回顾了从天然来源中分离吲哚咔唑类化合物以及此类化合物的生物合成，包括分子遗传学、酶学和代谢工程方面的最新进展。还介绍了天然和合成吲哚咔唑类化合物所表现出的生物活性及其潜在作用方式，重点是已进入临床试验以用于未来抗癌或其他疾病治疗的类似物的开发。
