微小RNA-21表达在肝细胞癌患者疾病进展中的临床意义
Clinical significance of microRNA-21 expression in disease progression of patients with hepatocellular carcinoma.
作者信息
Yoon Jun Sik, Kim Gyeonghwa, Lee Yu Rim, Park Soo Young, Tak Won Young, Kweon Young-Oh, Park Jung Gil, Lee Hye Won, Han Young Seok, Ha Heon Tak, Chun Jae Min, Jang Se Young, Hur Keun
机构信息
Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.
Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
出版信息
Biomark Med. 2018 Oct;12(10):1105-1114. doi: 10.2217/bmm-2018-0096. Epub 2018 Sep 7.
AIM
Aberrant microRNA (miR) expression is associated with hepatocellular carcinoma (HCC).
MATERIALS & METHODS: Here, we investigated the clinical significance of miR-21 and miR-31 for HCC-specific prognostic effect. HCC patients (n = 93) who underwent liver biopsy or surgical resection were enrolled, and HCC tissues and paired adjacent nontumor liver tissues were collected and analyzed for miRs expression.
RESULTS
MiR-21 expression was significantly upregulated in HCC tissues relative to nontumor tissues. Both miR-21 and miR-31 expression in HCC tissues did not predict overall survival; however, miR-21 was considered an independent predictor of disease progression together with portal vein thrombosis and higher Barcelona Clinical Liver Cancer stage.
CONCLUSION
Elevated miR-21 expression might represent a biomarker for HCC prognosis.
目的
异常的微小RNA（miR）表达与肝细胞癌（HCC）相关。
材料与方法
在此，我们研究了miR-21和miR-31对HCC特异性预后作用的临床意义。纳入了接受肝活检或手术切除的HCC患者（n = 93），收集HCC组织及配对的相邻非肿瘤肝组织，并分析miR表达。
结果
相对于非肿瘤组织，HCC组织中miR-21表达显著上调。HCC组织中miR-21和miR-31的表达均不能预测总生存期；然而，miR-21与门静脉血栓形成及更高的巴塞罗那临床肝癌分期一起被认为是疾病进展的独立预测因子。
结论
miR-21表达升高可能代表HCC预后的一个生物标志物。
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