Kanfer J N, Hattori H, Orihel D
Ann Neurol. 1986 Aug;20(2):265-7. doi: 10.1002/ana.410200214.
Biochemical examinations of brain tissue samples obtained from patients with Alzheimer's disease have revealed a decreased quantity of the neurotransmitter acetylcholine and reduced activity of choline acetyltransferase (ChAT), the enzyme responsible for acetylcholine formation. It has been suggested that the choline moiety of lecithin, a substitute ubiquitously present in membranes of mammalian cells, could be mobilized for acetylcholine formation. The activity of phospholipase D, an enzyme which releases choline directly from lecithin, was measured in homogenates of Alzheimer brain tissue and found to be reduced by 63%. ChAT activity was reduced by 58% and 5'-nucleotidase activity was reduced by 27% in these homogenates.
对从阿尔茨海默病患者获取的脑组织样本进行的生化检查显示，神经递质乙酰胆碱的量减少，且胆碱乙酰转移酶（ChAT）的活性降低，ChAT是负责乙酰胆碱形成的酶。有人提出，卵磷脂的胆碱部分（一种普遍存在于哺乳动物细胞膜中的替代物）可被调动用于乙酰胆碱的形成。在阿尔茨海默病脑组织匀浆中测量了磷脂酶D（一种直接从卵磷脂释放胆碱的酶）的活性，发现其降低了63%。在这些匀浆中，ChAT活性降低了58%，5'-核苷酸酶活性降低了27%。
