Department of Chemistry , RCSI , 123 St. Stephens Green , Dublin 2 , Ireland.
College of Pharmaceutical Sciences , Soochow University , 199 Ren'ai Rd., Suzhou Industrial Park , Soochow , Jiangsu , China , 215123.
Inorg Chem. 2018 Oct 1;57(19):12282-12290. doi: 10.1021/acs.inorgchem.8b01994. Epub 2018 Sep 7.
A novel 1,4-disubstituted 1,2,3-triazole-based ligand, 2-(4-(pyridin-2-yl)-1 H-1,2,3-triazol-1-yl)propane-1,3-diamine (ptpd), which possesses pyridyl and diamino secondary and tertiary coordinating groups was synthesized in excellent yield. The reactivity of 2-(1-phenyl-1 H-1,2,3-triazol-4-yl)pyridine (ptp), di- tert-butyl (2-azidopropane-1,3-diyl)dicarbamate (Boc-ptpd), and ptpd·3HCl was investigated with Au(III) and Pt(II) precursors. Analysis including X-ray crystal structures of [Au(III)Cl(ptp)] (1), [Au(III)Cl(ptpd)][Au(I)Cl][OH]{[NaAuCl·2HO]} n (3), and [Pt(II)Cl(ptpdH)][PtCl] (4) revealed that ptpd (i) serves as a monodentate ligand for Au(III) coordinating to the metal center via the pyridine nitrogen only, (ii) preferentially coordinates Au(III) via the bidentate diamino group over the monodentate pyridine group, (iii) can coordinate Pt(II) in a bidentate fashion via the pyridyl nitrogen and the triazole N-3, and (iv) can bridge two Pt(II) centers through bidentate chelation at the diamino group and bidentate chelation via the pyridyl nitrogen and the triazole N-3. ptpd represents a versatile ligand template for the development of mixed metal complexes.
一种新型的 1,4-二取代 1,2,3-三唑基配体 2-(4-(吡啶-2-基)-1 H-1,2,3-三唑-1-基)丙烷-1,3-二胺（ptpd），具有吡啶基和二氨基仲、叔配位基团，产率很高。研究了 2-(1-苯基-1 H-1,2,3-三唑-4-基)吡啶（ptp）、二-叔丁基（2-叠氮丙烷-1,3-二基）二碳酸酯（Boc-ptpd）和 ptpd·3HCl 与 Au(III)和 Pt(II)前体的反应性。包括 X 射线晶体结构分析 [Au(III)Cl(ptp)]（1）、[Au(III)Cl(ptpd)][Au(I)Cl][OH]{[NaAuCl·2HO]} n（3）和 [Pt(II)Cl(ptpdH)][PtCl]（4）表明，ptpd(i) 作为单齿配体通过吡啶氮原子与金属中心配位，仅 Au(III) 配位，(ii) 优先通过双齿二氨基基团与 Au(III)配位，而不是单齿吡啶基团，(iii) 可以通过吡啶氮原子和三唑 N-3 以双齿方式与 Pt(II)配位，(iv) 可以通过二氨基基团的双齿螯合和吡啶氮原子和三唑 N-3 的双齿螯合来桥接两个 Pt(II)中心。ptpd 代表一种多功能配体模板，可用于开发混合金属配合物。
