多发性硬化症患者胰岛素抵抗的代谢组学特征与疾病的严重程度有关。
Metabolomic profile of insulin resistance in patients with multiple sclerosis is associated to the severity of the disease.
机构信息
Laboratorios Clínicos de Puebla, Diaz Ordaz 808, Puebla, PUE, México; Universidad Popular Autónoma del Estado de Puebla, Calle 21 Sur 1103. Puebla, PUE, México.
Laboratorios Clínicos de Puebla, Diaz Ordaz 808, Puebla, PUE, México; Universidad Popular Autónoma del Estado de Puebla, Calle 21 Sur 1103. Puebla, PUE, México.
出版信息
Mult Scler Relat Disord. 2018 Oct;25:316-321. doi: 10.1016/j.msard.2018.08.014. Epub 2018 Aug 25.
BACKGROUND
Dysglycemia and adiposity have been related to disability in patients with multiple sclerosis. The objective of this work was to determine the prevalence and characteristics of insulin resistance in patients with multiple sclerosis using the metabolomics Quantose score.
METHODS
A total of 64 patients were accrued in the study. A blood sample was drawn to estimate the Quantose score, which is derived from fasting measurements of insulin, α-hydroxybutyrate, linoleoyl-glycerophosphocholine, and oleate, three nonglucose metabolites shown to correlate with insulin-stimulated glucose disposal.
RESULTS
Insulin resistance was documented in 33 out of 64 patients and it was found in association with the degree of disability and the time from diagnosis. Patients with the secondary progressive form of the disease showed the highest prevalence.
CONCLUSION
Insulin resistance is frequent in patients with multiple sclerosis and might contribute to metabolic complications and general disability. Early markers of dysglycemia should be sought for in these patients to avoid additional deterioration of their quality of life.
背景
糖代谢异常和肥胖与多发性硬化症患者的残疾有关。本研究旨在使用代谢组学 Quantose 评分来确定多发性硬化症患者胰岛素抵抗的患病率和特征。
方法
共纳入 64 例患者。采集血样以评估 Quantose 评分，该评分源自空腹胰岛素、α-羟基丁酸、亚油酸甘油磷酰胆碱和油酸三种非葡萄糖代谢物的测量值，这些代谢物与胰岛素刺激的葡萄糖摄取有关。
结果
64 例患者中有 33 例存在胰岛素抵抗，且与残疾程度和诊断后时间有关。疾病的继发性进展形式患者的患病率最高。
结论
多发性硬化症患者中胰岛素抵抗很常见，可能导致代谢并发症和整体残疾。应在这些患者中寻找早期的糖代谢异常标志物，以避免生活质量进一步恶化。
Zotero 插件