易于实现的硫醚化学选择性修饰生成手性中心诱导的螺旋肽。
Facile Chemoselective Modification of Thio-Ethers Generates Chiral Center-Induced Helical Peptides.
机构信息
State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology , Peking University Shenzhen Graduate School , Shenzhen , 518055 , China.
出版信息
Bioconjug Chem. 2018 Sep 19;29(9):2904-2908. doi: 10.1021/acs.bioconjchem.8b00624. Epub 2018 Sep 11.
Abstract
A precisely positioned sulfimide chiral center on-tether of a thio-ether tethered peptide determines the peptide secondary structure by chemoselective oxaziridine modification. This method provides a facile way to tune peptides' secondary structures and biophysical properties.
摘要
硫醚键连接的肽上精确定位的亚磺酰亚胺手性中心通过化学选择性噁唑啉修饰来确定肽的二级结构。该方法为调节肽的二级结构和生物物理性质提供了一种简便的方法。
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