Department of Psychology, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, United States; Department of Neuroscience, University of California San Francisco, San Francisco, California, United States.
Department of Psychology, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, United States.
Brain Res. 2018 Dec 15;1701:103-111. doi: 10.1016/j.brainres.2018.08.033. Epub 2018 Sep 5.
Oxidative stress has been implicated in both the functional and cognitive decline associated with neuropsychiatric diseases and aging. A master regulator of the body's defense mechanism against oxidative stress is nuclear factor erythroid 2-related factor (NRF2). Here we investigated the effects of NRF2 deletion on motor and cognitive performance in "Aged" mice (17-25 months old) as compared to "Mature" mice (3-15 months old). We observed that the Aged Nrf2 mice were hyperactive and exhibited impaired acquisition of an active avoidance response. Furthermore, the Mature mice also displayed a hyperactive phenotype and had impaired working memory in the probe trial of the water radial arm maze. Overall, it appears that NRF2 may be implicated in memory and activity functions and its deletion exacerbates deficits associated with aging. These observations provide a model for assessing the role of oxidative stress in age-related disorders.
氧化应激与神经精神疾病和衰老相关的功能和认知能力下降有关。核因子红细胞 2 相关因子（NRF2）是调节身体对抗氧化应激防御机制的主要调控因子。在这里，我们研究了 NRF2 缺失对“老年”（17-25 个月大）和“成熟”（3-15 个月大）小鼠的运动和认知表现的影响。我们观察到，老年 Nrf2 小鼠表现出过度活跃，并表现出主动回避反应获取能力受损。此外，成熟的小鼠在水放射臂迷宫的探测试验中也表现出过度活跃的表型和工作记忆受损。总的来说，NRF2 似乎与记忆和活动功能有关，其缺失加剧了与衰老相关的缺陷。这些观察结果为评估氧化应激在与年龄相关的疾病中的作用提供了一个模型。
