5-羟甲基糠醛对革兰氏阳性病原体的抗老化感应和生物膜潜能。
Antiquorum sensing and biofilm potential of 5- Hydroxymethylfurfural against Gram positive pathogens.
机构信息
Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, 608 502, Tamil Nadu, India.
Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, 608 502, Tamil Nadu, India.
出版信息
Microb Pathog. 2018 Dec;125:48-50. doi: 10.1016/j.micpath.2018.09.008. Epub 2018 Sep 6.
The present investigates the antiquorum sensing and biofilm inhibitory potential of 5 - hydroxymethylfurfural against Chromobacterium violaceum, Streptococcus pyogenes, Streptococcus mutans, Staphylococcus aureus and Staphylococcus epidermidis. 5HMF inhibits the quorum sensing mediated violacein pigment production by 87% at 100 μg/ml concentration. A 100 μg/ml concentration of the compound inhibits S. mutans and S. epidermidis biofilm formation by 86% and 79% whereas for S. pyogenes and S. aureus 125 μg/ml concentration inhibits biofilm formation by 83% and 82%. The Confocal images clearly indicate that 5HMF as a promising antibiofilm agent.
本研究调查了 5 - 羟甲基糠醛对紫色色杆菌、化脓性链球菌、变形链球菌、金黄色葡萄球菌和表皮葡萄球菌的抗老化感应和生物膜抑制潜力。在 100μg/ml 浓度下，5HMF 抑制群体感应介导的紫色素产生达 87%。该化合物的 100μg/ml 浓度可抑制 86%和 79%的变形链球菌和表皮葡萄球菌生物膜形成，而对于化脓性链球菌和金黄色葡萄球菌，125μg/ml 浓度可抑制 83%和 82%的生物膜形成。共聚焦图像清楚地表明，5HMF 是一种很有前途的抗生物膜剂。
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