Postgraduate Program in Nutrition, Universidade Federal de Pernambuco, Recife, PE, Brazil.
Department of Nutrition, Universidade Federal de Pernambuco, Recife, PE, Brazil.
Pharmacol Res. 2018 Oct;136:194-204. doi: 10.1016/j.phrs.2018.09.004. Epub 2018 Sep 6.
Selective Serotonin Reuptake Inhibitors (SSRIs) may have side effects, such as stiffness, tremors and altered tonic activity, as well as an increased risk of developing insulin resistance and diabetes mellitus. However, little is known about the structural, functional and metabolic changes of skeletal muscle after administration of SSRIs. The aim of this systematic review was to explore and discuss the effects of SSRIs on skeletal muscle properties described in human and rodent studies. A systematic search of PUBMED, SCOPUS, and WEB OF SCIENCE was performed. The inclusion criteria were intervention studies in humans and rodents that analysed the effects of SSRIs on skeletal muscle properties. The research found a total of six human studies, including two randomized controlled trials, one non-randomized controlled trial, one uncontrolled before-after study and two case reports, and six preclinical studies in rodents. Overall, the studies in humans and rodents showed altered electrical activity in skeletal muscle function, assessed through electromyography (EMG) and needle EMG in response to chronic treatment or local injection with SSRIs. In addition, rodent studies reported that SSRIs may exert effects on muscle weight, the number of myocytes and the cross-sectional area of skeletal muscle fibre. The results showed effects in energy metabolism associated with chronic SSRI use, reporting altered levels of glycogen synthase activity, acetyl-CoA carboxylase phosphorylation, citrate synthase activity, and protein kinase B Ser phosphorylation. Moreover, changes in insulin signalling and glucose uptake were documented. In this context, we concluded based on human and rodent studies that SSRIs affect electrical muscle activity, structural properties and energy metabolism in skeletal muscle tissue. However, these changes varied according to pre-existing metabolic and functional conditions in the rodents and humans.
选择性 5-羟色胺再摄取抑制剂（SSRIs）可能会有副作用，如僵硬、震颤和张力改变，以及增加发生胰岛素抵抗和糖尿病的风险。然而，对于 SSRIs 给药后骨骼肌的结构、功能和代谢变化知之甚少。本系统评价的目的是探讨和讨论在人类和啮齿动物研究中描述的 SSRIs 对骨骼肌特性的影响。对 PUBMED、SCOPUS 和 WEB OF SCIENCE 进行了系统搜索。纳入标准是分析 SSRIs 对骨骼肌特性影响的人类和啮齿动物干预研究。研究共发现 6 项人类研究，包括 2 项随机对照试验、1 项非随机对照试验、1 项无对照前后研究和 2 项病例报告，以及 6 项啮齿动物临床前研究。总体而言，人类和啮齿动物的研究表明，慢性治疗或局部注射 SSRIs 后，骨骼肌功能的电活动发生改变，通过肌电图（EMG）和针式肌电图进行评估。此外，啮齿动物研究报告称，SSRIs 可能对肌肉重量、肌细胞数量和骨骼肌纤维横截面积产生影响。研究结果表明，与慢性 SSRI 使用相关的能量代谢存在影响，报告了糖原合酶活性、乙酰辅酶 A 羧化酶磷酸化、柠檬酸合酶活性和蛋白激酶 B Ser 磷酸化水平的改变。此外，还记录了胰岛素信号和葡萄糖摄取的变化。基于人类和啮齿动物的研究，我们得出结论，SSRIs 影响骨骼肌组织的电肌肉活动、结构特性和能量代谢。然而，这些变化因啮齿动物和人类预先存在的代谢和功能状况而异。
