Li Guoli, Dong Sijing, Liu Chunhao, Yang Jing, Rensen Patrick C N, Wang Yanan
Med-X Institute, Center for Immunological and Metabolic Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Department of Endocrinology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Life Metab. 2024 Nov 23;4(2):loae039. doi: 10.1093/lifemeta/loae039. eCollection 2025 Apr.
Serotonin is one of the most potent gastrointestinal, peripheral, and neuronal signaling molecules and plays a key role in regulating energy metabolism. Accumulating evidence has shown the complex interplay between gut microbiota and host energy metabolism. In this review, we summarize recent findings on the role of gut microbiota in serotonin metabolism and discuss the complicated mechanisms by which serotonin, working in conjunction with the gut microbiota, affects total body energy metabolism in the host. Gut microbiota affects serotonin synthesis, storage, release, transport, and catabolism. In addition, serotonin plays an indispensable role in regulating host energy homeostasis through organ crosstalk and microbe-host communication, particularly with a wide array of serotonergic effects mediated by diverse serotonin receptors with unique tissue specificity. This fresh perspective will help broaden the understanding of serotonergic signaling in modulating energy metabolism, thus shedding light on the design of innovative serotonin-targeting strategies to treat metabolic diseases.
血清素是最强大的胃肠、外周和神经信号分子之一，在调节能量代谢中起关键作用。越来越多的证据表明肠道微生物群与宿主能量代谢之间存在复杂的相互作用。在这篇综述中，我们总结了肠道微生物群在血清素代谢中作用的最新发现，并讨论了血清素与肠道微生物群协同作用影响宿主全身能量代谢的复杂机制。肠道微生物群影响血清素的合成、储存、释放、运输和分解代谢。此外，血清素通过器官间相互作用和微生物与宿主的通讯在调节宿主能量稳态中发挥不可或缺的作用，特别是通过具有独特组织特异性的多种血清素受体介导的广泛血清素效应。这一新观点将有助于拓宽对血清素信号在调节能量代谢中作用的理解，从而为设计治疗代谢性疾病的创新血清素靶向策略提供思路。
