Division of Pediatric Intensive Care, Department of Pediatrics, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Faculty of Medicine, Department of Pediatrics, Division of Pediatric Emergency Care, Dokuz Eylul University, Izmir, Turkey.
Acta Neurol Belg. 2020 Feb;120(1):33-35. doi: 10.1007/s13760-018-1012-y. Epub 2018 Sep 8.
Baclofen is a derivative of gamma-aminobutyric acid, used mainly for the treatment of muscle spasticity. Baclofen overdose can result in severe respiratory depression, autonomic disturbances, seizures and coma. Here we report a 15-year-old girl who was found unresponsive, intubated and admitted to the PICU. On initial presentation, her Glasgow Coma Score was 3, with fixed dilated pupils. EEG revealed cerebral bioelectric activity and ground amplitudes significantly lower than normal. Supportive treatments were administered. On the 2nd PICU day, she regained consciousness and was able to follow commands. She was extubated and discharged on hospital day 3. Conclusively emergency physicians should consider baclofen overdose in children presenting with acute loss of consciousness, flaccidity, and hyporeflexia.
巴氯芬是γ-氨基丁酸的衍生物，主要用于治疗肌肉痉挛。巴氯芬过量可导致严重的呼吸抑制、自主神经紊乱、癫痫发作和昏迷。在这里，我们报告了一名 15 岁女孩，她被发现无反应，插管并被收入 PICU。最初表现时，她的格拉斯哥昏迷评分为 3 分，瞳孔固定扩大。脑电图显示脑生物电活动和地极幅度明显低于正常。给予支持性治疗。在 PICU 第 2 天，她恢复了意识并能够听从命令。她被拔管，并在住院第 3 天出院。总之，急诊医生应考虑巴氯芬过量的儿童出现急性意识丧失、弛缓性瘫痪和反射减弱。
