Dasgupta Kingshuk, Nielson Shelby
Pediatric Critical Care, Avera McKennan Children's Hospital and University Health Center, Sioux Falls, South Dakota.
Department of Pediatrics, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.
S D Med. 2020 Mar;73(3):106-110.
Baclofen (Lioresal) is a derivative of gamma-aminobutyric acid and is used in both adults and children mainly for symptomatic treatment of muscle spasticity. It is absorbed completely from the gastrointestinal tract, metabolized minimally in the liver and is excreted almost unchanged by the kidneys. Being lipophilic it can cross the blood-brain barrier easily. Baclofen overdose can result in life threatening complications such as respiratory failure, metabolic encephalopathy, seizures, deep coma and autonomic instability leading to hypertension and bradycardia.1-5 The literature on oral baclofen overdose in young children is very sparse. Here we report a 2-year-old-girl who was found by her parents after an accidental ingestion of her father's baclofen. The child presented with respiratory failure, coma, hypotonia and bradycardia. The patient was managed conservatively; mechanically ventilated for 16 hours and was discharged home after 48 hours with no sequelae.
巴氯芬（力奥来素）是γ-氨基丁酸的衍生物，主要用于成人和儿童肌肉痉挛的对症治疗。它可从胃肠道完全吸收，在肝脏中极少代谢，几乎以原形经肾脏排泄。因其具有亲脂性，所以能轻易穿过血脑屏障。巴氯芬过量可导致危及生命的并发症，如呼吸衰竭、代谢性脑病、癫痫发作、深度昏迷以及导致高血压和心动过缓的自主神经功能不稳定。1 - 5关于幼儿口服巴氯芬过量的文献非常稀少。在此，我们报告一名2岁女童，她在意外误服其父亲的巴氯芬后被父母发现。该患儿出现呼吸衰竭、昏迷、肌张力减退和心动过缓。患者接受了保守治疗；机械通气16小时，48小时后出院，无后遗症。
