Pan Z Z, Song Y N, Zhang Q, Yu J J, Zhang K N, Liang N, Zhang N, Ma X, Zhu J L, Zhe X Y, Xia H D T, Zheng W N, Li H T, Cao D D, Pan Z M
Department of Clinical Laboratory, the Fourth Division Hospital of Xinjiang Production and Construction Corps, Yili 835000, China.
Department of Clinical Laboratary, Friendship Hospital of Yili Kazak Autonomous Region of Xinjiang Uygur Autonomous Region, Yili 835000, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2018 Sep 6;52(9):946-950. doi: 10.3760/cma.j.issn.0253-9624.2018.09.015.
To investigate the infection status and genotype distribution of cervical human papillomavirus (HPV) in women of different ethnic groups and different ages in Yili, Xinjiang Uygur Autonomous Region (Xinjiang). By using the convenient sampling method, 54 760 women from November 2015 to May 2017 seeking for service in gynecological clinics in a general hospital in Yili, Xinjiang, were selected as the research subjects, and 3 445 samples of cervical mucous exfoliative cells were collected, and the social information of their ethnic and age was collected at the same time. The inclusion criteria were those with sexual life, cervical integrity, and ethnic groups for Han or Uygur or Kazak. PCR-reverse dot blot hybridization was used to detect HPV genotyping in exfoliated cells, and chi-square test was used to compare the difference of HPV positive rate among different ethnic groups. Then, according to ethnicity and age, the differences in positive rates of different ages and ethnic groups were compared in each layer. The positive rate of HPV was 25.6% (882 cases), of which the Han, Uygur and Kazakh were 27.9% (564 cases), 22.9% (196 cases) and 21.6% (122 cases), and the difference was statistically significant (χ(2)=13.80, 0.001). The most prevalent high-risk genotypes of Han women were HPV16/52/58, accounting for 24.8% (140 cases), 17.7% (100 cases) and 9.8% (55 cases), respectively. The most prevalent high-risk genotypes of Uygur women were HPV16/52/53, accounting for 34.2% (67 cases), 12.8% (25 cases), 9.2% (18 cases), respectively. The most prevalent high-risk genotypes of Kazak were HPV16/52/53, accounting for 37.7% (46 cases), 17.2% (21 cases), 12.3% (15 cases), respectively. The highest rate of HPV in Uygur patients aged ≥61 years was 41.5% (22 cases), and the lowest in group 36-40 years old, 15.9% (21 cases), the difference between different age groups was statistically significant (χ(2)=35.01, 0.001). The positive rate of HPV infection among Han, Uygur and Kazak in Yili Prefecture of Xinjiang was different, and the HPV positive genotype differs among different ethnic groups.
调查新疆维吾尔自治区伊犁地区不同民族、不同年龄女性宫颈人乳头瘤病毒（HPV）感染状况及基因型分布。采用方便抽样法，选取2015年11月至2017年5月在新疆伊犁某综合医院妇科门诊就诊的54 760名女性作为研究对象，采集3 445份宫颈黏膜脱落细胞样本，同时收集其民族、年龄等社会信息。纳入标准为有性生活、宫颈完整、民族为汉族或维吾尔族或哈萨克族。采用聚合酶链反应-反向斑点杂交法检测脱落细胞中HPV基因分型，采用卡方检验比较不同民族HPV阳性率差异。然后，按民族和年龄分层，比较各层不同年龄组和民族组阳性率差异。HPV阳性率为25.6%（882例），其中汉族、维吾尔族和哈萨克族分别为27.9%（564例）、22.9%（196例）和21.6%（122例），差异有统计学意义（χ(2)=13.80，P=0.001）。汉族女性最常见的高危基因型为HPV16/52/58，分别占24.8%（140例）、17.7%（100例）和9.8%（55例）。维吾尔族女性最常见的高危基因型为HPV16/52/53，分别占34.2%（67例）、12.8%（25例）、9.2%（18例）。哈萨克族最常见的高危基因型为HPV16/52/53，分别占37.7%（46例）、17.2%（21例）、12.3%（15例）。≥61岁维吾尔族患者HPV感染率最高，为41.5%（22例），36 - 40岁组最低，为15.9%（21例），不同年龄组差异有统计学意义（χ(2)=35.01，P=0.001）。新疆伊犁地区汉族、维吾尔族和哈萨克族HPV感染阳性率不同，且不同民族HPV阳性基因型存在差异。
