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中国新疆伊犁地区不同民族妇女宫颈细胞脱落物中人乳头瘤病毒感染的筛查。

Screening for HPV infection in exfoliated cervical cells of women from different ethnic groups in Yili, Xinjiang, China.

机构信息

Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Department of Biochemistry and Molecular Biology, School of Medicine, Shihezi University, Shihezi, 832002, Xinjiang, China.

Department of Clinical Laboratory, the Fourth Division Hospital of Xinjiang Production and Construction Corps, Yining, 835000, Xinjiang, China.

出版信息

Sci Rep. 2019 Mar 5;9(1):3468. doi: 10.1038/s41598-019-39790-2.

Abstract

We investigated the infection status and genotype distribution of human papillomavirus (HPV) in women of different ages and various ethnic groups in the Yili region, Xinjiang, China. We checked the HPV genotypes of 3,445 samples of exfoliated cervical cells using the PCR-reverse dot blot method. The total infection rate of HPV was 25.60% (882/3,445). The ethnic stratification showed that the infection rates were 22.87% (196/857) in Uygur, 21.55% (122/566) in Kazak, and 27.89% (564/2,022) in Han individuals. The most prevalent high-risk genotypes were HPV16, HPV52, and HPV53 in Uygur and Kazak and HPV16, HPV52, and HPV58 in Han ethnic groups. The age stratification showed that the infection rates in Han, Uygur, and Kazak women were up to 40.9% (61/149) in those aged 26-30 years, 41.5% (22/53) in those over 61 years old, and 30.2% (29/96) in those 46-50 years old, respectively. Therefore, HPV infection and HPV genotype distribution varied among the different age groups of the three ethnic groups.

摘要

我们调查了中国新疆伊犁地区不同年龄和不同民族女性的人乳头瘤病毒(HPV)感染状况和基因型分布。我们使用 PCR-反向斑点印迹法检查了 3445 例宫颈脱落细胞的 HPV 基因型。HPV 总感染率为 25.60%(882/3445)。民族分层显示,维吾尔族的感染率为 22.87%(196/857),哈萨克族为 21.55%(122/566),汉族为 27.89%(564/2022)。最常见的高危基因型是维吾尔族和哈萨克族的 HPV16、HPV52 和 HPV53,以及汉族的 HPV16、HPV52 和 HPV58。年龄分层显示,汉族、维吾尔族和哈萨克族女性的感染率在 26-30 岁年龄组中高达 40.9%(61/149),61 岁以上年龄组中高达 41.5%(22/53),46-50 岁年龄组中高达 30.2%(29/96)。因此,HPV 感染和 HPV 基因型分布在三个民族的不同年龄组中存在差异。

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