Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Department of Clinical Medicine, University of Bergen, Bergen, Norway; Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway.
J Neuroimmunol. 2018 Oct 15;323:73-77. doi: 10.1016/j.jneuroim.2018.07.011. Epub 2018 Jul 24.
Adipokines secreted by fatty tissue have inflammatory properties and are suggested biomarkers of MS disease activity. To assess this, 88 MS patients were followed with nine repeated measurements of leptin and adiponectin and 12 magnetic resonance imaging (MRI) scans for two years; six months without any immunomodulatory treatment followed by 18 months during interferon-beta (IFNB) treatment. Serum levels of leptin dropped and adiponectin increased upon initiation of IFNB-therapy, but were not associated with clinical or MRI disease activity or with treatment response. Our findings indicate that leptin and adiponectin are not useful as biomarkers of MS disease activity.
脂肪组织分泌的脂肪因子具有炎症特性，被认为是多发性硬化症（MS）疾病活动的生物标志物。为了评估这一点，88 名 MS 患者接受了为期两年的 9 次瘦素和脂联素重复测量和 12 次磁共振成像（MRI）扫描；6 个月无任何免疫调节治疗，随后在干扰素-β（IFNB）治疗期间 18 个月。IFNB 治疗开始时，血清瘦素水平下降，脂联素水平升高，但与临床或 MRI 疾病活动或治疗反应无关。我们的研究结果表明，瘦素和脂联素不能作为 MS 疾病活动的生物标志物。
