Zawilska J, Szmigielski A
Eur J Pharmacol. 1986 Jul 31;126(3):273-9. doi: 10.1016/0014-2999(86)90057-9.
The effect of repeated electroconvulsive shocks (ECS) on the responsiveness to isoprenaline of an endogenous, specific inhibitor of cAMP-dependent protein kinase (type I inhibitor) was tested in rat hippocampus and brainstem. Isoprenaline produced a dose-dependent decrease in the type I inhibitor activity in these brain structures. Neither the basal activity nor the isoprenaline-induced changes of type I inhibitor activity were affected by a single ECS. However, a series of 11 ECS markedly reduced the response of the type I inhibitor activity to isoprenaline. The action of isoprenaline was completely blocked by propranolol and markedly enhanced by aminophylline. The results indicate that the subsensitivity of beta-adrenoceptors is accompanied by reduced responsiveness of type I inhibitor activity to isoprenaline.
在大鼠海马体和脑干中测试了重复电惊厥休克（ECS）对环磷酸腺苷（cAMP）依赖性蛋白激酶内源性特异性抑制剂（I型抑制剂）对异丙肾上腺素反应性的影响。异丙肾上腺素使这些脑结构中I型抑制剂活性呈剂量依赖性降低。单次ECS既不影响I型抑制剂的基础活性，也不影响异丙肾上腺素诱导的I型抑制剂活性变化。然而，一系列11次ECS显著降低了I型抑制剂活性对异丙肾上腺素的反应。异丙肾上腺素的作用被普萘洛尔完全阻断，被氨茶碱显著增强。结果表明，β-肾上腺素能受体的敏感性降低伴随着I型抑制剂活性对异丙肾上腺素的反应性降低。
