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辣椒素敏感的大鼠输尿管抑制性神经支配的运动效应

The motor effect of the capsaicin-sensitive inhibitory innervation of the rat ureter.

作者信息

Maggi C A, Santicioli P, Giuliani S, Abelli L, Meli A

出版信息

Eur J Pharmacol. 1986 Jul 31;126(3):333-6. doi: 10.1016/0014-2999(86)90068-3.

DOI:10.1016/0014-2999(86)90068-3
PMID:3019720
Abstract

Neurokinins activate a series of tetrodotoxin (TTX)-insensitive rhythmic contractions of the rat isolated ureter. Field stimulation or capsaicin (1-3 microM) produced a transient inhibition of neurokinin-activated ureteral motility in preparations from control but not from capsaicin-pretreated (50 mg/kg s.c.) rats. The inhibitory action of field stimulation but not that of capsaicin was prevented by TTX. It is concluded that a capsaicin-sensitive inhibitory innervation exists in the rat ureter.

摘要

神经激肽可激活大鼠离体输尿管一系列对河豚毒素(TTX)不敏感的节律性收缩。在对照大鼠制备的标本中,场刺激或辣椒素(1 - 3微摩尔)可对神经激肽激活的输尿管运动产生短暂抑制,但在经辣椒素预处理(50毫克/千克皮下注射)的大鼠制备的标本中则不会。河豚毒素可阻断场刺激的抑制作用,但不能阻断辣椒素的抑制作用。由此得出结论,大鼠输尿管中存在对辣椒素敏感的抑制性神经支配。

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The motor effect of the capsaicin-sensitive inhibitory innervation of the rat ureter.辣椒素敏感的大鼠输尿管抑制性神经支配的运动效应
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2
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引用本文的文献

1
Effects of selective inhibitors of cyclo-oxygenase-1 (COX-1) and cyclo-oxygenase-2 (COX-2) on the spontaneous myogenic contractions in the upper urinary tract of the guinea-pig and rat.环氧化酶-1(COX-1)和环氧化酶-2(COX-2)选择性抑制剂对豚鼠和大鼠上尿路自发性肌源性收缩的影响。
Br J Pharmacol. 2000 Feb;129(4):661-70. doi: 10.1038/sj.bjp.0703104.
2
Neuropeptides in pelvic afferent pathways.盆腔传入通路中的神经肽
Experientia. 1987 Jul 15;43(7):801-13. doi: 10.1007/BF01945358.
3
Species-related differences in the capsaicin-sensitive innervation of the rat and guinea-pig ureter.
Naunyn Schmiedebergs Arch Pharmacol. 1988 Oct;338(4):407-10. doi: 10.1007/BF00172118.
4
Stimulation of afferent fibres of the guinea-pig ureter evokes potentials in inferior mesenteric ganglion neurones.刺激豚鼠输尿管的传入纤维可诱发肠系膜下神经节神经元产生电位。
J Physiol. 1988 Aug;402:543-53. doi: 10.1113/jphysiol.1988.sp017220.
5
Cutaneous lesions in capsaicin-pretreated rats. A trophic role of capsaicin-sensitive afferents?
Naunyn Schmiedebergs Arch Pharmacol. 1987 Nov;336(5):538-45. doi: 10.1007/BF00169311.
6
Capsaicin enhances the non-adrenergic twitch response of rat vas deferens.辣椒素增强大鼠输精管的非肾上腺素能抽搐反应。
Br J Pharmacol. 1987 Oct;92(2):469-75. doi: 10.1111/j.1476-5381.1987.tb11344.x.
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Regional differences in the effects of capsaicin and tachykinins on motor activity and vascular permeability of the rat lower urinary tract.辣椒素和速激肽对大鼠下尿路运动活性和血管通透性影响的区域差异。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Jun;335(6):636-45. doi: 10.1007/BF00166980.