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Species-related differences in the capsaicin-sensitive innervation of the rat and guinea-pig ureter.

作者信息

Amann R, Skofitsch G, Lembeck F

机构信息

Department of Experimental and Clinical Pharmacology, University of Graz, Austria.

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1988 Oct;338(4):407-10. doi: 10.1007/BF00172118.

DOI:10.1007/BF00172118
PMID:3266656
Abstract
  1. Comparison of the tissue content of calcitonin gene-related peptide (CGRP)-immunoreactivity (IR) and tachykinin (TK)-IR in the rat and guinea-pig ureter showed that in the rat tissue levels of CGRP-IR were 33-fold higher than those of TK-IR. In the guinea-pig ureter, both peptides were present in nearly the same concentration. 2. The in-vitro release of neuropeptides from guinea-pig and rat ureters was investigated using capsaicin as a stimulus for afferent neurons. Capsaicin induced the simultaneous release of CGRP-IR and TK-IR from the guinea-pig ureter while in the rat only the release of CGRP-IR was detectable. 3. It is known that TK potently stimulate and CGRP inhibits ureteric smooth muscle contractions. When the effect of capsaicin on ureteric motility was investigated in guinea-pig and rat, only in the guinea-pig ureter a stimulatory action ascribable to capsaicin-induced TK release was observed thus supplementing the results obtained by radioimmunoassay. 4. The results show that considerable species differences exist concerning the ratio of CGRP and TK which is stored and released from ureteric afferent nerve terminals. As a consequence, different functional responses are obtained in both species upon stimulation of these neurons by capsaicin. In the rat ureter, the capsaicin-sensitive innervation seems to be only inhibitory while in the guinea-pig stimulatory and inhibitory transmitters are released. The physiological significance of the simultaneous release of transmitters with opposing effects needs further investigation.
摘要

相似文献

1
Species-related differences in the capsaicin-sensitive innervation of the rat and guinea-pig ureter.
Naunyn Schmiedebergs Arch Pharmacol. 1988 Oct;338(4):407-10. doi: 10.1007/BF00172118.
2
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Neuroscience. 1987 Nov;23(2):693-703.
3
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Acta Physiol Scand Suppl. 1986;551:1-45.
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Calcitonin gene-related peptide (CGRP)-immunoreactive nerve plexuses in the renal pelvis and ureter of rats.

本文引用的文献

1
Substance P-like immunoreactivity in the intramural nerve plexuses of the guinea-pig ureter: a light and electron microscopical study.豚鼠输尿管壁内神经丛中P物质样免疫反应性：光镜和电镜研究
J Anat. 1981 Oct;133(Pt 3):425-42.
2
Degeneration of axons in the ureteric and duodenal nerve plexuses of the adult rat following in vivo treatment with capsaicin.
Neurosci Lett. 1981 Aug 7;25(1):19-24. doi: 10.1016/0304-3940(81)90094-x.
3
Plasma extravasation in the rat urinary bladder following mechanical, electrical and chemical stimuli: evidence for a new population of chemosensitive primary sensory afferents.机械、电和化学刺激后大鼠膀胱中的血浆外渗：新的化学敏感初级感觉传入神经群体的证据
Cell Tissue Res. 1992 Jan;267(1):29-33. doi: 10.1007/BF00318688.
4
Activation of primary afferent neurons by thermal stimulation. Influence of ruthenium red.热刺激对初级传入神经元的激活作用。钌红的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1990 Jan-Feb;341(1-2):108-13. doi: 10.1007/BF00195066.
Neurosci Lett. 1986 Dec 23;72(3):352-6. doi: 10.1016/0304-3940(86)90540-9.
4
Co-localization of tachykinins and calcitonin gene-related peptide in capsaicin-sensitive afferents in relation to motility effects on the human ureter in vitro.速激肽与降钙素基因相关肽在辣椒素敏感传入神经中的共定位及其对人输尿管体外运动的影响
Neuroscience. 1987 Nov;23(2):693-703.
5
Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides.辣椒素敏感感觉神经末梢的局部效应功能：速激肽、降钙素基因相关肽及其他神经肽的参与
Neuroscience. 1988 Mar;24(3):739-68. doi: 10.1016/0306-4522(88)90064-4.
6
The motor effect of the capsaicin-sensitive inhibitory innervation of the rat ureter.辣椒素敏感的大鼠输尿管抑制性神经支配的运动效应
Eur J Pharmacol. 1986 Jul 31;126(3):333-6. doi: 10.1016/0014-2999(86)90068-3.
7
Visceromotor responses to calcitonin gene-related peptide (CGRP) in the rat lower urinary tract: evidence for a transmitter role in the capsaicin-sensitive nerves of the ureter.
Eur J Pharmacol. 1987 Nov 3;143(1):73-82. doi: 10.1016/0014-2999(87)90736-9.
8
Involvement of a peripheral site of action in the early phase of neuropeptide depletion following capsaicin desensitization.辣椒素脱敏后神经肽耗竭早期阶段外周作用部位的参与情况。
Brain Res. 1987 Dec 15;436(2):402-6. doi: 10.1016/0006-8993(87)91688-x.
9
Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: distribution and release by capsaicin.动物和人类中辣椒素敏感的P物质免疫反应性感觉神经元中的降钙素基因相关肽（CGRP）：分布及辣椒素诱导的释放
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10
Pathway-specific patterns of the co-existence of substance P, calcitonin gene-related peptide, cholecystokinin and dynorphin in neurons of the dorsal root ganglia of the guinea-pig.豚鼠背根神经节神经元中P物质、降钙素基因相关肽、胆囊收缩素和强啡肽共存的通路特异性模式
Cell Tissue Res. 1987 May;248(2):417-37. doi: 10.1007/BF00218210.