Dashwood M R, Spyer K M
Eur J Pharmacol. 1986 Aug 15;127(3):279-82. doi: 10.1016/0014-2999(86)90376-6.
Using in vitro autoradiography the distribution of [3H]rauwolscine, [3H]prazosin and [3H]quinuclidinyl benzilate binding sites has been demonstrated in cardiac tissue taken from the cat and rat. A similar distribution of both alpha 1- and alpha 2-adrenoceptor sites was seen but the distribution of muscarinic acetylcholine sites was markedly different. alpha-Adrenoceptors were present predominantly in ventricular muscle whereas muscarinic acetylcholine receptors exhibited a greater density in atrial tissue compared to ventricular muscle. Opiate receptors were absent from cardiac tissue.
利用体外放射自显影技术，已在取自猫和大鼠的心脏组织中证实了[3H]萝芙木碱、[3H]哌唑嗪和[3H]东莨菪碱结合位点的分布。观察到α1和α2肾上腺素能受体位点的分布相似，但毒蕈碱型乙酰胆碱位点的分布明显不同。α肾上腺素能受体主要存在于心室肌中，而毒蕈碱型乙酰胆碱受体在心房组织中的密度比心室肌中更高。心脏组织中不存在阿片受体。
