Savchenko Lesia, Mykytiuk Marina, Cinato Mathieu, Tronchere Helene, Kunduzova Oxana, Kaidashev Igor
Ukrainian Medical Stomatological Academy, Poltava, Ukraine,
National Institute of Health and Medical Research (INSERM) U1048, Toulouse, France.
Int J Chron Obstruct Pulmon Dis. 2018 Aug 24;13:2569-2575. doi: 10.2147/COPD.S164833. eCollection 2018.
Chronic inflammatory process is the main link in COPD pathogenesis, which causes structural changes in the respiratory tract and lungs. In overweight patients, an adipose tissue could contribute to activation of the inflammatory process. Therefore, it is highly important to identify potential biomarkers of inflammation for patients with COPD and obesity. The aim of this study was to investigate the role of interleukin-26 (IL-26) and evaluate the relationship between the level of systemic inflammation, lung function, and body mass index (BMI) in patients with COPD.
Eighty-three patients with COPD in the stable condition (stage 2 according to the 2016 Global Initiative for Chronic Obstructive Lung Disease recommendations), aged 40-70 years, were included in the study. All patients were divided into 2 groups: obese (n=53) (BMI - 30.0-39.9 kg/m) and non-obese (n=30) (BMI - 18.5-24.9 kg/m). We conducted patients' examination, spirometry, induced the sputum, determined the level of C-reactive protein (CRP), leptin in serum and IL-26 in sputum.
Obese and non-obese COPD patients had a significant increase in IL-26 compared with healthy subjects by 2.3 and 2.6 (=0.0003). We also observed a higher level of CRP by 1.38 times (=0.0008), compared with the rate in non-obese COPD patients, and by 1.8 times (=0.015) higher concentration level of leptin compared with healthy subjects. The sputum IL-26 level had positive correlation with BMI, CRP, and leptin, and a negative - with forced expiratory volume in 1 second (FEV) and FEV/forced vital capacity. Leptin level had positive correlation with BMI and CRP, and negative with FEV, FEV/forced vital capacity.
Obese COPD patients had a higher level of persistent systemic inflammation than non-obese ones, which is confirmed by a significant increase of CRP and leptin in serum. The data confirm that IL-26 can be considered as a perspective marker to detect the inflammation level in lung tissue of COPD patients.
慢性炎症过程是慢性阻塞性肺疾病（COPD）发病机制的主要环节，可导致呼吸道和肺部的结构改变。在超重患者中，脂肪组织可能会促使炎症过程激活。因此，识别COPD和肥胖患者潜在的炎症生物标志物至关重要。本研究的目的是探讨白细胞介素-26（IL-26）的作用，并评估COPD患者全身炎症水平、肺功能和体重指数（BMI）之间的关系。
纳入83例处于稳定期（根据2016年慢性阻塞性肺疾病全球倡议建议为2期）、年龄在40至70岁之间的COPD患者。所有患者分为2组：肥胖组（n = 53）（BMI - 30.0 - 39.9 kg/m）和非肥胖组（n = 30）（BMI - 18.5 - 24.9 kg/m）。我们对患者进行了检查、肺功能测定、诱导痰液，测定了血清中C反应蛋白（CRP）、瘦素水平以及痰液中IL-26水平。
与健康受试者相比，肥胖和非肥胖COPD患者的IL-26水平显著升高，分别升高2.3倍和2.6倍（P = 0.0003）。与非肥胖COPD患者相比，我们还观察到CRP水平高1.38倍（P = 0.0008），与健康受试者相比，瘦素浓度水平高1.8倍（P = 0.015）。痰液IL-26水平与BMI、CRP和瘦素呈正相关，与第1秒用力呼气量（FEV1）和FEV1/用力肺活量呈负相关。瘦素水平与BMI和CRP呈正相关，与FEV1、FEV1/用力肺活量呈负相关。
肥胖COPD患者的持续全身炎症水平高于非肥胖患者，血清中CRP和瘦素的显著升高证实了这一点。数据证实IL-26可被视为检测COPD患者肺组织炎症水平的一个有前景的标志物。
