Rehman Zahid Ur, Alam Intikhab, Kamau Allan Anthony, Bajic Vladimir B, Leiknes TorOve
Water Desalination and Reuse Center (WDRC), Saudi Arabia.
Computational Bioscience Research Centre (CBRC), Biological & Environmental Science & Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
Biotechnol Rep (Amst). 2018 Aug 24;19:e00278. doi: 10.1016/j.btre.2018.e00278. eCollection 2018 Sep.
With antimicrobial resistance on the rise, the discovery of new compounds with novel structural scaffolds exhibiting antimicrobial properties has become an important area of research. Such compounds can serve as starting points for the development of new antimicrobials. In this report, we present the draft genome sequence of the strain VG4, isolated from Red Sea sediments, that produces metabolites with antimicrobial properties. A genomic analysis reveals that it carries at least five gene clusters that have the potential to direct biosynthesis of bioactive secondary metabolites such as polyketides and nonribosomal peptides. By using approaches, we predict the structure of these metabolites.
随着抗菌耐药性的不断上升，发现具有抗菌特性的新型结构支架的新化合物已成为一个重要的研究领域。这类化合物可作为开发新型抗菌药物的起点。在本报告中，我们展示了从红海沉积物中分离出的产生具有抗菌特性代谢物的菌株VG4的基因组序列草图。基因组分析表明，它携带至少五个有可能指导生物活性次级代谢产物（如聚酮化合物和非核糖体肽）生物合成的基因簇。通过使用相关方法，我们预测了这些代谢产物的结构。
