阿尼霉素产生菌链霉菌属TP-A0648的基因组序列草图
Draft Genome Sequence of an Anicemycin Producer, Streptomyces sp. TP-A0648.
作者信息
Komaki Hisayuki, Hosoyama Akira, Kimura Akane, Ichikawa Natsuko, Igarashi Yasuhiro
机构信息
Biological Resource Center, National Institute of Technology and Evaluation (NBRC), Chiba, Japan
NBRC, Tokyo, Japan.
出版信息
Genome Announc. 2017 Jan 12;5(2):e01468-16. doi: 10.1128/genomeA.01468-16.
Abstract
We report the draft genome sequence of Streptomyces sp. TP-A0648 isolated from a leaf of Aucuba japonica This strain produces a new tumor cell growth inhibitor designated anicemycin. The genome harbors at least 12 biosynthetic gene clusters for polyketides and nonribosomal peptides, suggesting the potential to produce diverse secondary metabolites.
摘要
我们报告了从日本桃叶珊瑚叶片中分离出的链霉菌属TP-A0648的基因组序列草图。该菌株产生一种名为阿尼霉素的新型肿瘤细胞生长抑制剂。该基因组含有至少12个聚酮化合物和非核糖体肽的生物合成基因簇，表明其具有产生多种次生代谢产物的潜力。
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