Roa J, Montoya G A
Gen Pharmacol. 1986;17(4):391-6. doi: 10.1016/0306-3623(86)90180-1.
An electrophysiological analysis has been made of the synaptic plasticity in the eighth sympathetic ganglion of the toad. The mean amplitude of Compound Action Potential (CAP) recorded extracellularly was taken as a measure of the synaptic transmission. Repetitive stimulation of the preganglionic axonal fibers at 50 Hz for 40 seconds in the presence of Hc-3 led to facilitatory and depressant actions on ganglionic synaptic transmission. Hc-3 in the presence of elevated extracellular Ca2+ concentration (5.4 mM) increased Tetanic Potentiation (TP) and Posttetanic Potentiation (PTP) on eighth sympathetic ganglion. Hc-3 plus 3,4-diaminopyridine (3,4-DAP) increased synaptic transmission, TP, and PTP from postganglionic CAP responses to supramaximal preganglionic stimulation.
对蟾蜍第八交感神经节的突触可塑性进行了电生理分析。细胞外记录的复合动作电位（CAP）的平均幅度被用作突触传递的指标。在存在六烃季铵（Hc-3）的情况下，以50Hz重复刺激节前轴突纤维40秒，对神经节突触传递产生易化和抑制作用。在细胞外Ca2+浓度升高（5.4mM）的情况下，Hc-3增加了第八交感神经节的强直增强（TP）和强直后增强（PTP）。Hc-3加3,4-二氨基吡啶（3,4-DAP）增加了节后CAP反应对超强节前刺激的突触传递、TP和PTP。
