Stolc S, Vlcková E
J Auton Nerv Syst. 1982 Nov;6(3):335-45. doi: 10.1016/0165-1838(82)90005-4.
Effects of 3,4-diaminopyridine and dimethylsulfoxide on transmission in frog sympathetic ganglion were analyzed. In the presence of either drug repetitive waves appeared in the compound action potential. Intracellular recording revealed a repetitive firing of certain populations of ganglionic neurons following each orthodromic stimulus. Antidromic stimulation did not evoke any repetitive response. Dependence of the repetitive response on drug concentration and stimulation rate is described. An enhancement and prolongation of fast EPSP was observed in the presence of both drugs. It is assumed that by interference with changes in membrane potassium permeability the drugs prolong the action potential in presynaptic terminals with a resulting increase in synaptic output of transmitter. The repetitive firing of the postsynaptic membrane subsequent to activation of the synapse is a consequence of its prolonged and more profound depolarization. Presumably, this is one of several mechanisms of drug-induced increase in efficacy of synaptic transmission in frog sympathetic ganglion known as stimulus-bound repetition.
分析了3,4 - 二氨基吡啶和二甲基亚砜对青蛙交感神经节传递的影响。在这两种药物存在的情况下，复合动作电位中出现了重复波。细胞内记录显示，每次顺向刺激后，某些神经节神经元群体会出现重复放电。逆向刺激未引发任何重复反应。描述了重复反应对药物浓度和刺激频率的依赖性。在两种药物存在的情况下，观察到快速兴奋性突触后电位（fast EPSP）增强和延长。据推测，这些药物通过干扰膜钾通透性的变化，延长了突触前终末的动作电位，从而导致递质的突触输出增加。突触激活后突触后膜的重复放电是其延长且更深度去极化的结果。据推测，这是药物诱导青蛙交感神经节突触传递效率增加（称为刺激绑定重复）的几种机制之一。
