通过未活化烯烃的无过渡金属芳基三氟甲基化反应合成含CFCH的二氢吲哚
Synthesis of CFCH-Containing Indolines by Transition-Metal-Free Aryltrifluoromethylation of Unactivated Alkenes.
作者信息
Liang Deqiang, Dong Qishan, Xu Penghui, Dong Ying, Li Weili, Ma Yinhai
机构信息
Department of Chemistry , Kunming University , Kunming 650214 , China.
Yunnan Engineering Technology Research Center for Plastic Films , Kunming 650214 , China.
出版信息
J Org Chem. 2018 Oct 5;83(19):11978-11986. doi: 10.1021/acs.joc.8b01861. Epub 2018 Sep 17.
With an unactivated double bond as the radical acceptor, allyl amines underwent a metal-free trifluoromethylation/cyclization cascade with CFSONa (Langlois' reagent), affording CFCH-containing indolines and tetrahydroisoquinolines, whose practical syntheses are significant challenges. This protocol features mild conditions, low cost, and a broad substrate scope.
以未活化的双键作为自由基受体，烯丙基胺与CFSONa（朗格卢瓦试剂）发生无金属三氟甲基化/环化串联反应，得到含CFCH的二氢吲哚和四氢异喹啉，其实际合成是重大挑战。该方法具有条件温和、成本低和底物范围广的特点。
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