无金属光氧化还原催化实现的烯烃分子间三氟甲基烯基化反应。
Intermolecular trifluoromethyl-alkenylation of alkenes enabled by metal-free photoredox catalysis.
作者信息
Kulthe Arun D, Mainkar Prathama S, Akondi Srirama Murthy
机构信息
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad-500007, India.
出版信息
Chem Commun (Camb). 2021 Jun 3;57(45):5582-5585. doi: 10.1039/d1cc01806j.
A three-component and redox-neutral trifluoromethylative alkenylation of unactivated alkenes with β-nitrostyrenes has been developed under visible-light. This metal-free protocol utilizes the easy to handle Langlois reagent (CF3SO2Na) as the CF3 source and is suitable for various unactivated alkenes and β-nitrostyrenes, affording a series of trifluoromethylated aromatic alkenes under mild conditions in good to excellent yields.
已开发出一种在可见光条件下，未活化烯烃与β-硝基苯乙烯的三组分、氧化还原中性三氟甲基化烯基化反应。该无金属方案使用易于处理的朗格卢瓦试剂（CF3SO2Na）作为CF3源，适用于各种未活化烯烃和β-硝基苯乙烯，能在温和条件下以良好至优异的产率得到一系列三氟甲基化芳香烯烃。
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