无金属三氟甲基化喹喔啉-2(1H)-酮与非活化烯烃和朗格卢瓦试剂。
Metal-Free Trifluoroalkylation of Quinoxalin-2(1)-ones with Unactivated Alkenes and Langlois' Reagent.
机构信息
School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong 273165, China.
School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China.
出版信息
J Org Chem. 2020 Jun 5;85(11):6888-6896. doi: 10.1021/acs.joc.9b03505. Epub 2020 May 11.
A KSO-mediated three-component protocol has been developed for the construction of 3-trifluoroalkylated quinoxalin-2(1)-ones under metal-free conditions. The present reaction could be accomplished through the trifluoroalkylation of quinoxalin-2(1)-ones with unactivated alkenes and Langlois' reagent (CFSONa), which provided a highly attractive approach to access a series of biologically important 3-trifluoroalkylated quinoxalin-2(1)-ones.
一种 KSO 介导的三组分反应协议已经被开发出来，用于在无金属条件下构建 3-三氟烷基化的喹喔啉-2(1)-酮。本反应可以通过喹喔啉-2(1)-酮与未活化的烯烃和 Langlois 试剂（CFSONa）的三氟烷基化来完成，这为合成一系列具有重要生物活性的 3-三氟烷基化的喹喔啉-2(1)-酮提供了一种极具吸引力的方法。
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