School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong 273165, China.
School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China.
J Org Chem. 2020 Jun 5;85(11):6888-6896. doi: 10.1021/acs.joc.9b03505. Epub 2020 May 11.
A KSO-mediated three-component protocol has been developed for the construction of 3-trifluoroalkylated quinoxalin-2(1)-ones under metal-free conditions. The present reaction could be accomplished through the trifluoroalkylation of quinoxalin-2(1)-ones with unactivated alkenes and Langlois' reagent (CFSONa), which provided a highly attractive approach to access a series of biologically important 3-trifluoroalkylated quinoxalin-2(1)-ones.
一种 KSO 介导的三组分反应协议已经被开发出来，用于在无金属条件下构建 3-三氟烷基化的喹喔啉-2(1)-酮。本反应可以通过喹喔啉-2(1)-酮与未活化的烯烃和 Langlois 试剂（CFSONa）的三氟烷基化来完成，这为合成一系列具有重要生物活性的 3-三氟烷基化的喹喔啉-2(1)-酮提供了一种极具吸引力的方法。
