Ruksha T G, Sergeeva E Yu, Palkina N V, Aksenenko M B, Komina A V, Klimina G M, Belonogov R N
Tsitologiia. 2016;58(10):733-43.
MicroRNAs belong to small non-coding RNA which regulate gene expression via mRNA degradation or translation inhibition. MicroRNAs are active modulators of gene expression in the skin caused by exogenous factors including ultraviolet irradiation. These effects are realized by targeting transcription factors and signaling systems components. Changes in microRNAs levels started to register in a few hours after exposure to ultraviolet irradiation, wich confirms the presence of an effective fast processes in the scin cells that modulate the functional status of microRNAs. The reported recently ability of microRNAs to be transported by exosomes may be related to systemic effects of ultraviolet irradiation that include the altered immune response and systemic inflammatory reaction. Understanding these processes is important because of the possibility of purposeful influence on the expression and activity of a microRNA that may have implications for diagnosis and therapy of photodermatosis and malignant skin tumors.
微小RNA属于小非编码RNA，其通过mRNA降解或翻译抑制来调节基因表达。微小RNA是由包括紫外线照射在内的外源性因素引起的皮肤基因表达的活性调节剂。这些作用是通过靶向转录因子和信号系统成分来实现的。在暴露于紫外线照射后数小时内就开始记录到微小RNA水平的变化，这证实了皮肤细胞中存在调节微小RNA功能状态的有效快速过程。最近报道的微小RNA被外泌体运输的能力可能与紫外线照射的全身效应有关，包括免疫反应改变和全身炎症反应。由于有可能有目的地影响微小RNA的表达和活性，而这可能对光皮肤病和恶性皮肤肿瘤的诊断和治疗有影响，因此了解这些过程很重要。
