Dolgova Dinara, Abakumova Tatiana, Gening Tatiana, Poludnyakova Ludmila, Zolotovskii Igor, Stoliarov Dmitrii, Fotiadi Andrei, Khokhlova Anna, Rafailov Edik, Sokolovski Sergei
Department of Physiology and Pathophysiology, Faculty of Medicine, Ulyanovsk State University,42 Leo Tolstoy Street, Ulyanovsk 432017, Russia.
S.P. Kapitsa Technological Research Institute, Ulyanovsk State University, 42 Leo Tolstoy Street, Ulyanovsk 432017, Russia.
Biomed Opt Express. 2019 Jul 31;10(8):4261-4275. doi: 10.1364/BOE.10.004261. eCollection 2019 Aug 1.
Recently, many interdisciplinary community researchers have focused their efforts on study of the low-level light irradiation effects (photobiomodulation, PBM) as a promising therapeutic technology. Among the priorities, a search of new wavelength ranges of laser radiation to enhance the laser prospects in treatment of autoimmune and cancer diseases commonly accompanied by disorders in the antioxidant system of the body. The laser wavelengths within 1265-1270 nm corresponds to the maximum oxygen absorption band. Therefore, PBM effects on a model organism within this spectrum range are of particular interest for preclinical research. Here, we report comprehensive biomolecular studies of the changes in the BALB/c nude mice skin after an exposure to the continuous laser radiation at the 1270 nm wavelength and energy densities of 0.12 and 1.2 J/cm. Such regime induces both local and systemic PBM effects, presumably due to the short-term increase in ROS levels, which in turn activate the cell antioxidative system.
最近，许多跨学科的社区研究人员致力于研究低水平光照射效应（光生物调节作用，PBM），将其作为一种有前景的治疗技术。其中的重点之一是寻找激光辐射的新波长范围，以增强激光在治疗通常伴有身体抗氧化系统紊乱的自身免疫性疾病和癌症方面的前景。1265 - 1270纳米范围内的激光波长对应于最大氧吸收带。因此，在此光谱范围内对模式生物的光生物调节作用效应对于临床前研究尤为重要。在此，我们报告了对BALB/c裸鼠皮肤在暴露于波长为1270纳米、能量密度为0.12和1.2焦耳/平方厘米的连续激光辐射后变化的综合生物分子研究。这种照射方式会引发局部和全身的光生物调节作用效应，可能是由于活性氧水平的短期升高，进而激活了细胞抗氧化系统。
