Department of Dermatology and.
Department of Internal Medicine, School of Medicine, UCD, Sacramento, California, USA.
J Clin Invest. 2018 Oct 1;128(10):4251-4253. doi: 10.1172/JCI123121. Epub 2018 Sep 10.
In spite of a very robust body of literature and definitive data demonstrating the importance of the programmed cell death receptor-1 (PD-1) pathway in T cells and their function, the data on NK cell PD-1 expression have been highly variable and, particularly in the case of mouse NK cells, scarce. In this issue of the JCI, Hsu et al. present data demonstrating PD-1 expression on mouse NK cells only within tumors and show that PD-1 blockade elicits an antitumor NK cell-mediated response. This study indicates that, given the complexity of both the biology and study of NK cells, further work is needed to more clearly determine the role of the PD-1/PD-1 ligand (PD-L1) on NK cells.
尽管有大量的文献和明确的数据表明程序性细胞死亡受体 1（PD-1）通路在 T 细胞及其功能中的重要性，但关于 NK 细胞 PD-1 表达的数据一直存在很大的差异，特别是在小鼠 NK 细胞的情况下，数据非常匮乏。在本期 JCI 中，Hsu 等人提供的数据表明，只有在肿瘤中才会在小鼠 NK 细胞上表达 PD-1，并表明 PD-1 阻断会引发抗肿瘤 NK 细胞介导的反应。这项研究表明，鉴于 NK 细胞的生物学和研究的复杂性，需要进一步的工作来更清楚地确定 PD-1/PD-1 配体（PD-L1）对 NK 细胞的作用。
