Tokyo University of Pharmacy and Life Sciences , 1432-1 Horinouchi , Hachioji , Tokyo 192-0392 , Japan.
Org Lett. 2018 Sep 21;20(18):5569-5572. doi: 10.1021/acs.orglett.8b02241. Epub 2018 Sep 10.
The use of diaminomethylenemalononitrile (DMM) organocatalyst to promote the challenging 1,2-hydrophosphonylation of simple ketones and enones, which are also called α,β-unsaturated ketones, is proposed and validated. This reaction provided the corresponding chiral α-hydroxy phosphonates in high to excellent yields and with enantioselectivity up to 96% ee.
提出并验证了二氨基亚甲基丙二腈（DMM）有机催化剂在促进具有挑战性的简单酮和烯酮（也称为α，β-不饱和酮）的 1,2-氢膦酰化反应中的应用。该反应以高至优异的收率和高达 96%ee 的对映选择性提供了相应的手性α-羟基膦酸酯。
