School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan.
Chem Asian J. 2022 Feb 14;17(4):e202101299. doi: 10.1002/asia.202101299. Epub 2022 Jan 12.
A novel N,N-dibenzyl diaminomethylenemalononitrile organocatalyst efficiently promoted asymmetric Henry reactions of trifluoromethyl enones with nitromethane, affording corresponding highly functionalized products in high yields with excellent enantioselectivities (up to 90% ee). This study is the first to report the successful example of the asymmetric 1,2-additions of nitromethane to trifluoromethyl enones.
一种新型的 N,N-二苄基二氨亚甲基丙二腈有机催化剂有效地促进了三氟甲基烯酮与硝基甲烷的不对称 Henry 反应，以高收率和优异的对映选择性（高达 90%ee）得到了相应的高官能化产物。本研究首次报道了硝基甲烷对三氟甲基烯酮的不对称 1,2-加成的成功实例。
