Nagappa Mahesh, Subramani Yamini, Chung Frances
Department of Anesthesiology and Perioperative Medicine, University Hospital, Victoria Hospital and St. Joseph's Hospital, London Health Sciences and St. Joseph's Healthcare, Western University, London.
Department of Anesthesiology, University of Toronto.
Curr Opin Anaesthesiol. 2018 Dec;31(6):700-706. doi: 10.1097/ACO.0000000000000661.
The perioperative outcome in obstructive sleep apnea (OSA) patients undergoing ambulatory surgery can be potentially impacted by the type of anesthetic technique, fluid management and choice of anesthetic agents. This review highlights the best perioperative practices in the management of OSA patients undergoing ambulatory surgical procedures.
A recent meta-analysis found that STOP-Bang might be used as a perioperative risk stratification tool. Patients with high-risk OSA (STOP-Bang ≥3) were found to be associated with an increased risk of postoperative complications and prolonged length of hospital stay compared with low-risk OSA (STOP-Bang 0-2) patients undergoing noncardiac surgical procedures. A bidirectional relationship exists between OSA and difficult airway. Both suspected or diagnosed OSA may be associated with either difficult intubation or difficult mask ventilation or both. A recent meta-analysis identified OSA as an important risk factor for opioid-induced respiratory depression. A dose-response relationship was shown between the morphine equivalent daily dose and death or near-death events in OSA patients undergoing surgery. Postoperative continuous monitoring is recommended for high-risk OSA patients receiving opioids. Minimising the dose of muscle relaxant, neuromuscular monitoring and ensuring complete reversal of neuromuscular blockade before extubation is essential in OSA patients to avoid postoperative complications. Whenever feasible, regional anesthesia with multimodal analgesia may be considered as a better alternative to general anesthesia in OSA patients.
Patients with OSA and associated comorbidities present a challenge to anesthesiologists as they are at a high risk of perioperative complications. It is important to identify patients with OSA, with the goal to raise awareness among providers, mitigate risk and improve outcomes.
门诊手术的阻塞性睡眠呼吸暂停(OSA)患者围手术期结局可能受到麻醉技术类型、液体管理和麻醉药物选择的潜在影响。本综述重点介绍了门诊手术的OSA患者围手术期管理的最佳实践。
最近的一项荟萃分析发现,STOP-Bang可能用作围手术期风险分层工具。与接受非心脏手术的低风险OSA(STOP-Bang 0-2)患者相比,高风险OSA(STOP-Bang≥3)患者术后并发症风险增加,住院时间延长。OSA与困难气道之间存在双向关系。疑似或确诊的OSA都可能与插管困难或面罩通气困难或两者都有关。最近的一项荟萃分析确定OSA是阿片类药物引起的呼吸抑制的重要危险因素。在接受手术的OSA患者中,吗啡等效日剂量与死亡或濒死事件之间存在剂量反应关系。建议对接受阿片类药物的高风险OSA患者进行术后持续监测。对于OSA患者,尽量减少肌肉松弛剂剂量、进行神经肌肉监测并确保拔管前神经肌肉阻滞完全逆转对于避免术后并发症至关重要。只要可行,在OSA患者中,区域麻醉联合多模式镇痛可能是比全身麻醉更好的选择。
OSA及相关合并症患者给麻醉医生带来了挑战,因为他们围手术期并发症风险很高。识别OSA患者很重要,目的是提高医护人员的认识、降低风险并改善结局。