(3-N-[11C]甲基)司哌隆的改进合成方法。
An improved synthesis of (3-N-[11C]methyl)spiperone.
作者信息
Dannals R F, Ravert H T, Wilson A A, Wagner H N
出版信息
Int J Rad Appl Instrum A. 1986;37(5):433-4. doi: 10.1016/0883-2889(86)90100-0.
An improved radiochemical synthesis of (3-N-[11C]methyl) spiperone is reported. The radiotracer was prepared by N-alkylation of spiperone in dimethylformamide in the presence of equimolar aqueous tetrabutylammonium hydroxide and was purified by semi-preparative reversed phase high performance liquid chromatography (C-18 HPLC). The average radiochemical yield was approximately 21% end-of-synthesis (EOS) with an average specific activity of over 2750 mCi/mumol EOS. The total time for synthesis and specific activity determination was approximately 21 min.
报道了一种改进的（3-N-[¹¹C]甲基）螺哌隆的放射化学合成方法。该放射性示踪剂是在等摩尔的氢氧化四丁基铵水溶液存在下，于二甲基甲酰胺中通过螺哌隆的N-烷基化反应制备的，并通过半制备反相高效液相色谱（C-18 HPLC）进行纯化。合成结束时（EOS）的平均放射化学产率约为21%，EOS时的平均比活超过2750 mCi/μmol。合成和比活测定的总时间约为21分钟。
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