From the Brighton and Sussex Medical School.
Royal Alexandra Children's Hospital, Brighton, United Kingdom.
Pediatr Infect Dis J. 2019 Feb;38(2):146-148. doi: 10.1097/INF.0000000000002143.
We assessed HIV antibody prevalence in children with perinatally acquired HIV in England. Eighteen percent (10/55) of those starting combination antiretroviral therapy <6 months of age were seronegative at median age 9.1 years and had lower viral load at diagnosis and combination antiretroviral therapy start and fewer viral rebounds, than 45 of 55 seropositives. Implications for patient selection for HIV cure research, and interpretation of routine antibody testing, are discussed.
我们评估了英国围生期感染 HIV 的儿童的 HIV 抗体流行率。18%（10/55）在 6 个月龄以下开始联合抗逆转录病毒治疗的儿童在中位年龄 9.1 岁时血清学阴性，且诊断时和开始联合抗逆转录病毒治疗时的病毒载量较低，病毒反弹也较少，而 55 例血清阳性者中则有 45 例存在这种情况。讨论了对 HIV 治愈研究中患者选择的影响，以及对常规抗体检测的解释。
