Lauriola Michele, Mangiacotti Antonio, D'Onofrio Grazia, Cascavilla Leandro, Paris Francesco, Ciccone Filomena, Greco Monica, Paroni Giulia, Seripa Davide, Greco Antonio
Complex Unit of Geriatrics, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Complex Unit of Geriatrics, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo,
Dement Geriatr Cogn Disord. 2018;46(3-4):140-153. doi: 10.1159/000492489. Epub 2018 Sep 10.
BACKGROUND/AIM: The aim of the study was to evaluate the prognostic power of late-life depression (LLD) compared with amnestic mild cognitive impairment (aMCI) for the onset of Alzheimer's disease (AD) within 4 years of follow-up.
We estimated the incidence of AD in 60 patients presenting with aMCI, 115 patients suffering of LLD treated with antidepressants with good compliance, and 66 healthy control (HC) patients, followed for 4 years.
The risk to develop AD, within 4 years, was 68.33% for aMCI and 49.57% for LLD. In AD patients 5.60% deteriorated without depression, and 72.20% deteriorated with depression after 4 years of follow-up (p < 0.0001). No HC patients deteriorated to AD or any other dementia type.
In our results, aMCI was the first predictive condition that increased the risk to develop AD. Depression is a potentially preventable medical condition across the lifespan and may be a modifiable risk factor.
背景/目的：本研究的目的是评估与遗忘型轻度认知障碍（aMCI）相比，晚年抑郁症（LLD）在4年随访期内对阿尔茨海默病（AD）发病的预测能力。
我们对60例aMCI患者、115例接受依从性良好的抗抑郁药治疗的LLD患者以及66例健康对照（HC）患者进行了4年的随访，评估AD的发病率。
4年内，aMCI患者发生AD的风险为68.33%，LLD患者为49.57%。随访4年后，AD患者中5.60%在无抑郁状态下病情恶化，72.20%在伴有抑郁状态下病情恶化（p<0.0001）。没有HC患者恶化为AD或任何其他痴呆类型。
在我们的研究结果中，aMCI是增加AD发病风险的首要预测因素。抑郁症是一种在整个生命周期中可能预防的疾病状态，可能是一个可改变的风险因素。
