Zheng Haiyan, Xu Weilin, Chen Yili, Gai Shiying, Chen Gao
Department of Neurosurgery, Fourth Affiliated Hospital, Yiwu Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Medicine (Baltimore). 2018 Sep;97(36):e11587. doi: 10.1097/MD.0000000000011587.
Deep cerebral venous thrombosis (DCVT) is a rare disease, but always results in poor prognosis.
We reported a 79-year-old female with coma after traumatic brain injury (TBI).
The epidural hematoma was first diagnosed on non-contrast computerized tomography (CT). The hypodense areas in bilateral thalami and basal ganglia on reexamination CT highly indicated the suspicion of DCVT. Finally, the appearance of thrombosis of the vein of Galen on the computed tomography venography (CTA) and digital subtraction angiography (DSA) confirmed the diagnosis.
The patients received surgery to remove the epidural hematoma. After that, she was treated with oral anticoagulation agent (low molecular weight heparin (LMWH), 180 Axal U/kg 24 h) for 4 weeks, shifted by oral warfarin (2.5 mg qd) for 4 weeks.
The hypodense areas in bilateral thalami and basal ganglia have been largely reversed. At the time of 6 months after surgery, the patient could take care of herself.
If the CT shows hypodense areas in bilateral thalami and basal ganglia, a diagnosis of DCVT should be suspected once the patients could not recover from the treatment of primary diseases.
大脑深部静脉血栓形成(DCVT)是一种罕见疾病,但预后往往较差。
我们报告了一名79岁女性,在创伤性脑损伤(TBI)后昏迷。
首次非增强计算机断层扫描(CT)诊断为硬膜外血肿。复查CT时双侧丘脑和基底节的低密度区高度提示怀疑DCVT。最后,计算机断层扫描静脉造影(CTA)和数字减影血管造影(DSA)显示大脑大静脉血栓形成,确诊。
患者接受了硬膜外血肿清除手术。之后,她接受了4周的口服抗凝剂治疗(低分子量肝素(LMWH),180抗Xa单位/千克,每24小时一次),随后换用口服华法林(2.5毫克,每日一次)治疗4周。
双侧丘脑和基底节的低密度区已基本恢复。术后6个月时,患者能够自理。
如果CT显示双侧丘脑和基底节有低密度区,一旦患者在原发性疾病治疗后无法恢复,应怀疑诊断为DCVT。