Wang Xuqin, Zhou Guoqi, Zeng Jiaying, Yang Ting, Chen Jie, Li Tingyu
Children's Nutrition Research Center Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Chongqing Third Affiliated Hospital of Zunyi Medical College, Guizhou, PR China.
Medicine (Baltimore). 2018 Sep;97(36):e11849. doi: 10.1097/MD.0000000000011849.
The purpose of this study was to summarize the evidences from randomized controlled trials (RCTs) investigating the effects of educational interventions in overweight/obesity childhood by using meta-analytic approach.
PubMed, Embase, and the Cochrane Library databases were searched from the inception to April 2018. Weighted mean differences (WMDs) with corresponding 95% confidence intervals (CIs) were used to measure the effects of educational interventions during childhood in the random-effects models.
Thirty RCTs reporting data on 35,296 children were included in the meta-analysis. The summary WMD indicated that children received educational interventions had lower levels of body mass index (BMI) (WMD: -0.15; 95% CI: -0.24 to -0.05; P = .003), BMI z-score (WMD: -0.03; 95% CI: -0.05 to -0.02; P < .001), waist circumference (WMD: -0.97; 95% CI: -1.95 to -0.00; P = 0.050), triceps skinfold (WMD: -1.39; 95% CI: -2.41 to -0.37; P = .008), systolic blood pressure (WMD: -1.13; 95% CI: -2.20 to -0.07; P = .037), total cholesterol (WMD: -4.04; 95% CI: -7.18 to -0.90; P = .012), and triglyceride (WMD: -2.62; 95% CI: -4.33 to -0.90; P = .003). However, educational interventions were not associated with the levels of waist-to-hip ratio, diastolic blood pressure, high-density lipoprotein, and low-density lipoprotein.
The study findings elucidate the positive effects of educational interventions on BMI, BMI z-score, waist circumference, triceps skinfold, systolic blood pressure, total cholesterol, and triglyceride.
本研究的目的是采用荟萃分析方法总结随机对照试验(RCT)中有关教育干预对儿童超重/肥胖影响的证据。
检索了从建库至2018年4月的PubMed、Embase和Cochrane图书馆数据库。在随机效应模型中,采用加权平均差(WMD)及相应的95%置信区间(CI)来衡量儿童期教育干预的效果。
30项报告了35296名儿童数据的RCT被纳入荟萃分析。汇总的WMD表明,接受教育干预的儿童体重指数(BMI)水平较低(WMD:-0.15;95%CI:-0.24至-0.05;P = 0.003)、BMI z评分(WMD:-0.03;95%CI:-0.05至-0.02;P < 0.001)、腰围(WMD:-0.97;95%CI:-1.95至-0.00;P = 0.050)、肱三头肌皮褶厚度(WMD:-1.39;95%CI:-2.41至-0.37;P = 0.008)、收缩压(WMD:-1.13;95%CI:-2.20至-0.07;P = 0.037)、总胆固醇(WMD:-4.04;95%CI:-7.18至-0.90;P = 0.012)和甘油三酯(WMD:-2.62;95%CI:-4.33至-0.90;P = 0.003)。然而,教育干预与腰臀比、舒张压、高密度脂蛋白和低密度脂蛋白水平无关。
研究结果阐明了教育干预对BMI、BMI z评分、腰围、肱三头肌皮褶厚度、收缩压、总胆固醇和甘油三酯的积极影响。