Song Jin Hwa, Lee Chang-Hoon, Kim Deog Keom, Yoon HyoungKyu, Byun Min Kwang, Rhee Chin Kook, Lee Jaechun, Kim Woo Jin, Hwang Yong Il, Yoo Kwang Ha, Jung Ki Suck
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital Division of Pulmonary and Critical Care Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center Department of Internal Medicine, Seoul National University College of Medicine, Seoul Division of Pulmonology, Department of Internal Medicine, St. Mary's Hospital, College of Medicine, The Catholic University of Korea Division of Pulmonology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul Department of Internal Medicine, Jeju National University School of Medicine, Jeju Department of Internal Medicine and Environmental Health Center, Kangwon National University, Kangwon-do Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University Medical School, Gyoenggi-do Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
Medicine (Baltimore). 2018 Sep;97(36):e12049. doi: 10.1097/MD.0000000000012049.
Asthma and chronic obstructive pulmonary disease (COPD) are common chronic airway diseases. Overlap in the clinical features of these 2 diseases is observed in many cases, and thus, the concept of asthma-COPD overlap (ACO) has recently been proposed. However, the definition of ACO and the clinical significance remains to be determined.We evaluated the prevalence and risk of acute exacerbation in ACO among Korean COPD patients as defined by modified Spanish criteria and American Thoracic Society (ATS) Roundtable criteria.The prevalence of ACO was 47.7% (660/1383) by modified Spanish criteria and 1.9% (26/1383) by ATS Roundtable criteria. ACO, regardless of criteria, did not significant affect the exacerbation risk during at least 1-year follow-up period.Substantial discrepancies were found in the prevalence and outcome of ACO according to different diagnostic criteria, which would compromise implementation of ACO before the definition is established.
哮喘和慢性阻塞性肺疾病（COPD）是常见的慢性气道疾病。在许多病例中观察到这两种疾病临床特征存在重叠，因此，最近提出了哮喘-慢性阻塞性肺疾病重叠（ACO）的概念。然而，ACO的定义和临床意义仍有待确定。我们根据改良的西班牙标准和美国胸科学会（ATS）圆桌会议标准，评估了韩国慢性阻塞性肺疾病患者中ACO的患病率和急性加重风险。根据改良的西班牙标准，ACO的患病率为47.7%（660/1383），根据ATS圆桌会议标准为1.9%（26/1383）。无论采用何种标准，ACO在至少1年的随访期内对加重风险均无显著影响。根据不同诊断标准，ACO的患病率和结果存在显著差异，这将在定义确定之前影响ACO的实施。
