热灌注腹腔化疗在晚期卵巢癌治疗中的应用
Heated Intraperitoneal Chemotherapy in the Management of Advanced Ovarian Cancer.
作者信息
Jewell Andrea, McMahon Megan, Khabele Dineo
机构信息
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Kansas Medical Center, Kansas, KS 66160, USA.
出版信息
Cancers (Basel). 2018 Sep 1;10(9):296. doi: 10.3390/cancers10090296.
Abstract
Heated intraperitoneal chemotherapy (HIPEC) has several potential benefits. Higher doses of chemotherapy can be used with HIPEC because the plasma-peritoneal barrier results in little absorption into the blood stream. HIPEC offers higher peritoneal penetration in comparison to an intravenous (IV) regimen and does not have the traditional normothermic intraperitoneal (IP) regimen limitation of post-operative adhesions. Hyperthermia itself has cytotoxic effects and can potentiate antineoplastic effects of chemotherapy in part by increasing the depth of tumor penetration by up to 3 mm. For the treatment of ovarian cancer, HIPEC has been evaluated in the recurrent setting with secondary cytoreduction. Recent studies, including a prospective trial, have evaluated its role in primary management of ovarian cancer. This review summarizes previous and ongoing studies regarding the use of HIPEC in the management of ovarian cancer.
摘要
热腹腔内化疗（HIPEC）有几个潜在益处。由于血浆-腹膜屏障导致化疗药物很少吸收进入血流，因此HIPEC可使用更高剂量的化疗药物。与静脉（IV）化疗方案相比，HIPEC能使化疗药物在腹膜内有更高的渗透，并且没有传统常温腹腔内（IP）化疗方案术后粘连的局限性。热疗本身具有细胞毒性作用，并且部分地通过将肿瘤渗透深度增加多达3毫米来增强化疗的抗肿瘤作用。对于卵巢癌的治疗，已在复发性卵巢癌行二次肿瘤细胞减灭术时对HIPEC进行了评估。包括一项前瞻性试验在内的近期研究，已评估了其在卵巢癌初始治疗中的作用。本综述总结了以往及正在进行的关于HIPEC在卵巢癌治疗中应用的研究。
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