Marrelli Daniele, Ansaloni Luca, Federici Orietta, Asero Salvatore, Carbone Ludovico, Marano Luigi, Baiocchi Gianluca, Vaira Marco, Coccolini Federico, Di Giorgio Andrea, Framarini Massimo, Gelmini Roberta, Palopoli Carmen, Accarpio Fabio, Fagotti Anna
Unit of General Surgery and Surgical Oncology, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
Unit of General Surgery San Matteo Hospital, 27100 Pavia, Italy.
Cancers (Basel). 2022 Dec 6;14(23):6010. doi: 10.3390/cancers14236010.
Ovarian cancer is the eighth most common neoplasm in women with a high mortality rate mainly due to a marked propensity for peritoneal spread directly at diagnosis, as well as tumor recurrence after radical surgical treatment. Treatments for peritoneal metastases have to be designed from a patient's perspective and focus on meaningful measures of benefit. Hyperthermic intraperitoneal chemotherapy (HIPEC), a strategy combining maximal cytoreductive surgery with regional chemotherapy, has been proposed to treat advanced ovarian cancer. Preliminary results to date have shown promising results, with improved survival outcomes and tumor regression. As knowledge about the disease process increases, practice guidelines will continue to evolve. In this review, we have reported a broad overview of advanced ovarian cancer management, and an update of the current evidence. The future perspectives of the Italian Society of Surgical Oncology (SICO) are discussed conclusively.
卵巢癌是女性中第八大常见肿瘤，死亡率很高，主要原因是在诊断时就有明显的腹膜播散倾向，以及根治性手术治疗后肿瘤复发。腹膜转移瘤的治疗必须从患者角度出发进行设计，并侧重于有意义的获益指标。腹腔内热化疗（HIPEC）是一种将最大程度减瘤手术与区域化疗相结合的策略，已被用于治疗晚期卵巢癌。迄今为止的初步结果显示出了有前景的结果，包括生存结局改善和肿瘤消退。随着对疾病过程的了解不断增加，实践指南将持续演变。在本综述中，我们报告了晚期卵巢癌管理的广泛概述以及当前证据的更新情况。最后讨论了意大利外科肿瘤学会（SICO）的未来展望。
