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基于真实世界研究的银花泌炎灵片使用者的临床特征

[Clinical characteristics of Yinhua Miyanling Pian users based on real world study].

作者信息

Sun Jin, Xie Yan-Ming, Liu Huan, Zhang Yin, Zhang Yong-Sheng, Zhuang Yan

机构信息

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Institute of Basic Medical Science of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2018 Aug;43(16):3391-3396. doi: 10.19540/j.cnki.cjcmm.2018.0098.

Abstract

Clinical characteristics of Yinhua Miyanling Pian user group were analyzed based on real world hospital information system (HIS)database. The information was collected from the HIS in sixteen hospitals of grade Ⅲ-A. Normalizing the data and descriptive analysis was performed. Among the 5 312 cases, female patients(63.67%) were more than male patients (36.33%). The median age was 49 years old. The age of 18-65 accounted for 74.52%.The patient was admitted to the hospital's department of obstetrics and gynecology(28.71%) and urology(28.43%). The median single dose is 2 g, accounted for 49.55%. The median daily dose is 6 g. 88.80% of patients were treated for less than 7 d. The median hospitalization were 12 d, most were 7-14 d accounted for 41.70%. Most hospitalization expenses payment by medicare, accounted for 80.22%. The median hospitalization expenses was 12 211.47 RMB. Most patients with benign tumor(27.36%) and malignant tumor(15.56%), next is the obstruction of urinary tract(15.49%) and urinary calculi(10.52%). The most common syndromes were damp heat syndrome(32.46%), liver and kidney deficiency syndrome(15.33%) and splenasthenic fluid-retention syndrome(15.01%). Clinical use is combined with antibiotics, as well as traditional Chinese medicine heat clearing agents, tonic drugs and so on. Finally, 44.22% were cured and 51.05% were better. Most of the drug users were adults, and mostly were female. Most with the tumor, urinary tract obstruction or stones. TCM syndrome is mainly characterized by dampness and heat, deficiency of liver and kidney, and dampness of spleen. In clinical practice, it was mainly combined with Western medicines, and Chinese medicines were also a-vailable. And most are combined with antibiotics.The medication basically conforms to the drug instruction. Based on the results of the real world HIS,Yinhua Miyanling Pian could provide theidea and reference for regulating the medication in adolescent patients.

摘要

基于真实世界医院信息系统(HIS)数据库,分析银花泌炎灵片使用者群体的临床特征。信息收集自16家三级甲等医院的HIS。进行数据归一化和描述性分析。在5312例病例中,女性患者(63.67%)多于男性患者(36.33%)。年龄中位数为49岁。18 - 65岁的患者占74.52%。患者入住医院妇产科(28.71%)和泌尿外科(28.43%)。单次剂量中位数为2g,占49.55%。每日剂量中位数为6g。88.80%的患者治疗时间少于7天。住院时间中位数为12天,大部分为7 - 14天,占41.70%。大部分住院费用由医疗保险支付,占80.22%。住院费用中位数为12211.47元。大多数患者患有良性肿瘤(27.36%)和恶性肿瘤(15.56%),其次是尿路梗阻(15.49%)和尿路结石(10.52%)。最常见的证型为湿热证(32.46%)、肝肾亏虚证(15.33%)和脾虚湿蕴证(15.01%)。临床用药联合抗生素,以及中药清热剂、滋补类药物等。最后,44.22%治愈和51.05%好转。大多数用药者为成年人,且大多为女性。大多数患有肿瘤、尿路梗阻或结石。中医证型主要表现为湿热、肝肾亏虚和脾虚湿蕴。临床实践中主要联合西药,也有中药可用。且大多联合抗生素。用药基本符合药品说明书。基于真实世界HIS的结果,银花泌炎灵片可为规范青少年患者用药提供思路和参考。

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