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银花泌炎灵片治疗泌尿系统感染的临床与基础研究

[Clinical and fundamental research Yinhua Miyanling Tablets in treating urinary tract infection].

作者信息

Zhang Wen-Ting, Miao Run-Pei, Zhao Qi-Han, Sun Yue, Han Shuai-Jie, Yang Han-Wen, Xiong Min, Yu Guo-Yong, Wang Yao-Xian

机构信息

Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Beijing 100700, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2019 Jun;44(11):2403-2410. doi: 10.19540/j.cnki.cjcmm.20190117.004.

Abstract

As the famous Chinese patent medicine, Yinhua Miyanling Tablets, which was derived from ancient prescription denominated Bazhengsan, has not only the effects in clearing away heat and purging pathogenic fire, removing dampness and relieving stranguria, but also have the functions of detoxifying and tonifying. A great number of scientific studies have demonstrated that Yinhua Mi-yanling Tablets played significant roles in destroying harmful microbes and resisting inflammatory and diuresis. Compared with antibiotics, traditional antibacterial Chinese patent medicine Yinhua Miyanling Tablets has the advantage in bacterial resistance in long-term use. Fundamental studies about the content of pharmaceutical ingredients and the modern pharmacology of Yinhua Miyanling Tablets were collected and summarized, which conduces to indicating the active ingredients of Yinhua Miyanling Tablets with the medicinal efficacy from the molecular level and the internal mechanism of Yinhua Miyanling Tablets in the treatment of urinary tract infection(UTI) from the scientific perspective. In the field of clinical research, literatures associated with Yinhua Miyanling Tablets for the treatment of UTI were summarized and analyzed in terms of treatment type, administration mode, dosage, frequency of medication, course, efficiency, side effects and whether combined with healthy lifestyle. These literatures confirmed the medicinal values and the application prospect of Yinhua Miyanling Tablets in treating UTI, especially acute UTI, which provides a scientific theoretical foundation and a correct direction for the clinical application of Yinhua Miyanling Tablets. In conclusion, this article contributes to the standardization of Yinhua Miyanling Tablets in the treatment of UTI, in the expectation of giving the scientific guidance for clinical practice.

摘要

作为著名的中成药,银花泌炎灵片源自古代方剂八正散,不仅具有清热泻火、利湿通淋的功效,还具有解毒扶正的作用。大量科学研究表明,银花泌炎灵片在杀灭有害微生物、抗炎和利尿方面发挥着重要作用。与抗生素相比,传统抗菌中成药银花泌炎灵片在长期使用时具有细菌耐药性方面的优势。收集并总结了关于银花泌炎灵片药物成分含量及现代药理学的基础研究,这有助于从分子水平指明银花泌炎灵片具有药效的活性成分,并从科学角度揭示银花泌炎灵片治疗尿路感染(UTI)的内在机制。在临床研究领域,对与银花泌炎灵片治疗UTI相关的文献,从治疗类型、给药方式、剂量、用药频率、疗程、疗效、副作用以及是否结合健康生活方式等方面进行了总结和分析。这些文献证实了银花泌炎灵片在治疗UTI,尤其是急性UTI方面的药用价值和应用前景,为银花泌炎灵片的临床应用提供了科学的理论基础和正确方向。总之,本文有助于规范银花泌炎灵片在UTI治疗中的应用,期望为临床实践提供科学指导。

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